Victor Chernomordik Curriculum Vitae

Victor V. Chernomordik, Ph.D.
3 Radburn Ct.
Rockville, MD 20850

Tel: (301) 838 3185 (h)
(301) 435 9236 (w)

Email address: vchern@helix.nih.gov

Education:

  • Ph.D. in Theoretical Physics, April 1977, Moscow Institute of Physics and Technology and the Lebedev Physical Institute of the Academy of Sciences of the USSR (Advisors Prof. Leonid M. Ozernoy and Nobel Prize Winner (2003) Acad. Vitaly L. Ginsburg)
  • M.S. in Theoretical Physics, July 1973, General and Applied Physics Department of the Moscow Institute of Physics and Technology, USSR (Advisor Dr. Vladimir N. Sazonov)
  • B.S. in Radiophysics, July 1971, Radiophysics Department of the Moscow Institute of Physics and Technology, USSR

Positions:

April 2004 – Present Staff Scientist, Laboratory of Integrative and Medical Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland
March 2000 – April 2004 Senior Research Fellow, Laboratory of Integrative and Medical Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland
October 1997 – March 2000 Contractor-consultant, Laboratory of Integrative and Medical Biophysics, NICHD, National Institutes of Health, Bethesda, Maryland
September 1995 – October 1997 Contractor-consultant, Physical Sciences Laboratory, DCRT, National Institutes of Health, Bethesda, Maryland
December 1991 – June 1995 Senior Scientist, Head of Research Group, Scientific Council on Cybernetics, Russian Academy of Sciences, Moscow, Russia
November 1989 – November 1991 Senior Scientist, Head of Research Group, Computer Aided Design Institute, Academy of Sciences of the USSR, Moscow, USSR
October 1981 – November 1989 Senior Research Fellow, Head of the Research Group in Almaz State Corporation, Moscow, USSR
October 1976 – October 1981 Junior Research Fellow in Almaz State Corporation, Moscow, USSR
September 1973 – September 1976 Post Graduate Course in Theoretical Physics and Astrophysics, Department of General and Applied Physics, the Moscow Institute of Physics and Technology
September 1971 – June 1973 Undergraduate student research program, Department of Theoretical Physics, The Lebedev Physical Institute, Academy of Sciences of the USSR

Honors:

  • Diploma of the graduation from the Moscow Institute of Physics and Technology with the special distinction, June 1973.
  • Special State Medal for the most distinguished students of high schools, June 1966

Research Interests:

  • Theory of photon migration in turbid media, in particular, biological tissues
  • Reconstruction algorithms, allowing to map deeply embedded tissue abnormalities, quantify their optical parameters and derive their physiological status
  • Time-resolved fluorescence imaging of fluorophores inside the turbid media
  • Application of fluorescence imaging, using contrast agents to target specific cell receptors for an “optical biopsy” of tissue abnormalities
  • Quantitative assessment of overexpression of specific receptors, using optical methods to monitor the therapy of cancer
  • Polarization imaging

Reviewer for:

  • Optical-MRI SBIR Applications Committee,
  • BAA, NCI Committee (Novel Technologies for Noninvasive Detection, Diagnosis and Treatment of Cancer)
  • Optics Letters
  • Applied Optics
  • Optics Express
  • Physics in Medicine and Biology
  • Journal of Biomedical Optics
  • Physical Review
  • Applied Physics Letters
  • Proceedings of the National Academy of Sciences
  • Biophysical Journal
  • Biomedical Optics Express

Section Chair at:

  • Annual Meeting of the Optical Society of America
  • Annual International Conference of the IEEE Engineering in Medicine and Biology Society
  • Metropolitan Biophotonics Symposium, 2009

Member of the Program Committee:

  • Inter-institute, Optical Imaging Workshops at NIH: 1999, 2000, 2002, 2004, 2006, 2009

Invited Speaker at:

  • 5th Molecular Imaging in Drug Discovery and Development Conference, 2011, Philadelphia, USA
  • International Conference, SPIE Workshop on Coherent Optics of Ordered and Random Media VI, Saratov, Russia, 2005
  • International Symposium on Biomedical Optics (BIOS ’09), 2011, San Francisco, California USA
  • International Symposium on Biomedical Optics (BIOS ’09), 2009, San Jose, California USA
  • International Conference on Advanced Laser Technologies (Focused on Biomedical Optics), Silsoe, UK, 2003 

Bibiography:

  1. V.V. Chernomordik, "Cyclotron mechanism of polarization of optical radiation from white dwarfs", Astron. Tsirc. of the USSR Academy of Sciences, v. 768, pp. 6-8, 1973.
  2. V.N. Sazonov and V.V. Chernomordik, "Polarization of optical radiation from magnetic white dwarfs", Astrophysics and Space Science, v. 32, pp. 355-360, 1975.
  3. L.M. Ozernoy and V.V. Chernomordik, "On the production of Deuterium and Helium-3 in active galactic nuclei", Soviet Astronomy v. 19, pp. 693-700,1975.
  4. L.M. Ozernoy and V.V. Chernomordik, "Bright phase in the evolution of galaxies and ionization of intergalactic gas", Soviet Astronomy v. 20, pp. 260-273, 1976.
  5. L.M. Ozernoy and V.V. Chernomordik, "Cavities in the intergalactic medium", Sov. Astronomy Letters, v. 2, pp. 145-153, 1976.
  6. L.M. Ozernoy and V.V. Chernomordik, "Shock waves in the Metagalaxy at large redshifts", Soviet Astronomy v. 22, pp. 141-151, 1978.
  7. V.V. Chernomordik and L.M. Ozernoy, "Intergalactic shock waves", Nature, vol. 303, pp. 153-155, 1983.
  8. V.V. Chernomordik and L.M. Ozernoy, "Signposts of shock waves in the metagalactic medium", Astrophysics and Space Science, v. 97, pp. 19-43, 1983.
  9. Aggeev, M.V. Issakov, V.A. Martynov, V.V. Morozov, V.V. Chernomordik, "The destruction of thin slabs by radiation", 1984, Physics and Chemistry of Material Processing of the USSR Academy of Sciences, v. 5, 9-11 (in Russian).
  10. L.M. Ozernoy and V.V. Chernomordik, "Unsaturated character of the La absorption line observed from cosmic voids", Astron. Tsirc. of the USSR Academy of Sciences, v. 1407, pp. 1-3, 1985.
  11. L.M. Ozernoy and V.V. Chernomordik, "A test for the explosional origin of cosmic voids", Astron. Tsirc. of the USSR Academy of Sciences, v. 1408, pp. 3-5, 1985.
  12. L.M. Ozernoy and V.V. Chernomordik, "Using of gravitationally-lensed quasar to constrain the models of La forest", Astron. Tsirc. of the USSR Academy of Sciences, v. 1436, pp. 1-3 1986.
  13. L.M. Ozernoy and V.V. Chernomordik, "Gas in a cosmic void: properties and origin", Sov. Astronomy Letters, v. 12, part 2, pp. 135-145, 1986.
  14. V.V. Chernomordik, "On the nature of the La forest", Sov. Astronomy, v. 32(1), pp. 6-13, 1988.
  15. V.V. Chernomordik, "Structure of the absorption spectra of the quasars Q 0420-388 and Q 1101-264", Sov. Astronomy, v. 32(4), pp. 362-366, 1988.
  16. V.V. Chernomordik, L.M. Ozernoy, "The quasars proximity effect in an equivalent-width-limited sample of the Lyman-alpha forest", Astrophysical Journal, 404:L5-L8, 1993.
  17. V.N Adrov & V.V. Chernomordik, "Mathematical simulation of pressure pulse propagation in biological tissues in the presence of phase abberations", 1994, Ultrasonic Imaging, v. 15, 59-71.
  18. V.V. Chernomordik, "Evidence for small-scale clustering in a column-density-limited sample of the Lyman-alpha forest", 1995, Astrophysical Journal, v.440, 431-434.
  19. V.V. Chernomordik, "Small-scale clustering in a column-density-limited sample of the Lyman-alpha forest", 1995, in QSO Absorption Lines, Proceedings of the ESO Workshop held at Garching, Germany, November 1994, ed. G. Meylan, (Springer-Verlag), 343.
  20. V.N. Adrov & V.V. Chernomordik, "Simulation of two-dimensional ultrasonic imaging of biological tissues in the presence of phase aberrations", 1995, Ultrasonic Imaging, v. 17, 27-43.
  21. V. Chernomordik, R. Nossal & A.H. Gandjbakche, “Point spread functions of photons in time-resolved transillumination experiments using simple scaling arguments”, 1996, Medical Physics, v. 23(11), 1-4.
  22. Amir H. Gandjbakhche, Victor Chernomordik, Jeremy C. Hebden, and Ralph Nossal, “Use of Time-Dependent Contrasts Functions for Quantitative Imaging in Time-Resolved Transillumination Experiments”, 1998, Applied Optics, v. 37(10), 1973-1981.
  23. Victor Chernomordik, Amir H. Gandjbakhche, Jeremy C. Hebden and Giovanni Zaccanti, “Effect of lateral boundaries on contrast functions in time-resolved transillumination measurements”, 1999, Medical Physics v. 26(9), 1822-1831.
  24. Victor Chernomordik, David Hattery, Antonio Pifferi, Paola Taroni, Alessandro Torricelli, Gianluca Valentini, Rinaldo Cubeddu, andAmir H. Gandjbakhche, “A random walk methodology for quantification of the optical characteristics of abnormalities embedded within tissue-like phantoms”, 2000, Optics Letters, v. 25(13), 951-953.
  25. Victor Chernomordik, David Hattery, andAmir H. Gandjbakhche, “Quantitative Optical Imaging Using Random Walk Theory”, Proceedings of Inter-Institute Workshop on In-Vivo Optical Imaging at the NIH, Amir H. Gandjbakhche, ed. (Optical Society of America, Washington, DC 2000), pp.188-193.
  26. D. Hattery, V. Chernomordik, M. Loew, I. Gannot, and A. Gandjbakhche, “Analytical Solutions for Time-Resolved Fluorescence Lifetime Imaging in a Turbid Medium Such as Tissue”, 2001, JOSA(A), v. 18(7), 1523-1530.
  27. Victor Chernomordik, Amir Gandjbakhche, Maria Lepore, Rosario Esposito, and Ines Delfino, “Depth Dependence of the Analytical Expression for the Width of the Point Spread Function (Spatial Resolution) in Time-resolved Transillumination”, 2001, J. Biomed Opt., 6(4), 441-445.
  28. Victor Chernomordik, David W. Hattery, Dirk Grosenick, Heidrun Wabnitz, Herbert Rinneberg, K. Thomas Moesta, Peter M. Schlag, and Amir Gandjbakhche, “Quantification of Optical Properties of a Breast Tumor Using Random Walk Theory”, 2002, J. Biomed. Opt., 7(1), 80-87.
  29. Victor Chernomordik, David W. Hattery, Israel Gannot,Giovanni Zaccanti, and Amir Gandjbakhche, “Analytical Calculation of the Mean Time Spent by Photons inside an Absorptive Inclusion Embedded in a Highly Scattering Medium”, 2002, J. Biomed. Opt., 7(3), 486-492.
  30. Alec Eidsath, Victor Chernomordik, Amir Gandjbakhche, Paul Smith, and Angelo Russo, “3-D localization of fluorescent masses deeply embedded in tissue”, 2002, Phys Med Biol. 47, 4079-4092.
  31. D. L. Sackett, V. Chernomordik, S. Krueger, and R. Nossal, “Use of small-angle neutron scattering (SANS) to study tubulin polymers”, 2003, BioMacromolecules, 4(2), 461-467.
  32. Israel Gannot, Avital Garashi, Gallya Gannot, Victor Chernomordik, and Amir Gandjbakhche, “In-vivo Quantitative 3-D Localization of Tumor Labeled with Exogenous Specific Fluorescence Markers”, 2003, Appl. Opt., 42(16), 3073-3080
  33. Amir H. Gandjbakhche, Victor Chernomordik, David Hattery, Moinuddin Hassan and Israel Gannot, "Tissue characterization by quantitative optical imaging methods", Technology in Cancer Research and Treatment, 2003, v.2(6), 537-551
  34. D. Hattery, B. Hattery, M. Hassan, V. Chernomordik, A. Vogel, F. Hekmat, and A. Gandjbakhche, “Optical Quantification of Epithelial Layer Thickness as a Measure of Oral inflamation”, 2004, J. Biomed. Opt., 9(5) 951-960.
  35. Israel Gannot*, Victor Chernomordik*, Avital Garashi, and Amir Gandjbakhche, “Quantitative optical imaging of pharmacokinetics of specific fluorescent tumor markers through turbid media such as tissue”, 2004, Optics Letters, 29(7), 742-744, (authors, marked *, contributed equally)
  36. Olga K. Dudko, George H. Weiss, Victor Chernomordik, and Amir H. Gandjbakhche, “Photon Migration in Turbid media with Anisotropic Optical Properties”, 2004, Phys. Med. Biol., 49, 3979-3989.
  37. Israel Gannot, Ron Izhar, Farid Hekmat, Victor Chernomordik and Amir Gandjbakhche, “Functional optical imaging based on pH dependent fluorescence lifetime”, Lasers in Surgery and Medicine, 2004, 35(5): 342-348.
  38. Jeremy C. Hebden, Jorge J. Garcia Guerrero, Victor Chernomordik, and Amir H. Gandjbakhche, “Experimental evaluation of an anisotropic scattering model for a slab geometry”, 2004, Optics Letters, 29(21), 2518-2520.
  39. Nicole Y. Morgan, Sean English, Wei Chen, Victor Chernomordik, Angelo Russo, Paul D. Smith, and Amir Gandjbakhche, Real timenon-invasive optical imaging in vivo with near-infrared quantum dots”, Academic Radiology, 2005 12(3): 313-323.
  40. A. Sviridov, V. Chernomordik, A. Russo, A. Eidsath, P. Smith, M. Hassan, and A. Gandjbakhche, "Intensity profiles of linearly polarized light backscattered from skin and tissue-like phantoms", 2005, J. Biomed. Opt., 10(1), CID 014012.
  41. A. Sviridov, V. Chernomordik, M. Hassan, A. Russo, P. Smith, and A. Gandjbakhche, “Use of Pearce correlation analysis to visualize a hidden structure of early fibrosis by polarized digital photography”,2005, J. Biomed. Opt., 10(5): CID 051706.
  42. L. Dagdug*, V. Chernomordik*, G.H. Weiss, and A.H. Gandjbakhche, “Monte Carlo Simulations of Increased/Decreased Scattering Inclusions inside a Turbid Slab”, 2005, Phys. Med. Biol., 50(23): 5573-5581, (authors, marked *, contributed equally).
  43. A. Small, I. Illev, V. Chernomordik, and A.H. Gandjbakhche, “Enhancing diffraction-limited images, using properties of the point spread function”, 2006, Optics Express, 14(8), 3193-3203
  44. Olga K. Dudko, George H. Weiss, and Victor Chernomordik, “Mean time-of-flight of photons in transillumination measurements of optically anisotropic tissue with an inclusion”, 2006, Phys. Med. Biol. 51, 4719-4733
  45. A.P. Sviridov, Z. Ulissi, V. Chernomordik, M. Hassan, and A.H. Gandjbakhche, “Visualization of Biological Texture Using Correlation Coefficient Images", 2006, J. Biomed. Opt. Lett., 11:060504
  46. M. Hassan, J. Riley, V. Chernomordik, P. Smith, R. Pursley, S. B. Lee, J. Capala, A.H. Gandjbakhche, "Fluorescence Lifetime Imaging System for InVivo Studies", 2007, Molecular Imaging 6(4), 229-236
  47. A. Vogel, M. Hassan, F. Amyot, V. Chernomordik, B. Dasgeb, S.G. Demos, R. Pursley, R. Little, R. Yarchoan, Y. Tao, and A. H. Gandjbakhche, "Using Non-Invasive Multi-Spectral Imaging to Quantitatively Assess Tissue Vasculature", 2007, J. Biomed. Opt., 12, 051604 (Nov. 1, 2007)
  48. B. Lin, V. Chernomordik, A. Gandjbakhche, D. Matthews, and S. Demos, “Investigation of Signal Dependence on Tissue Depth in Near Infrared Spectral Imaging”, 2007, Optics Express, 15(25) (12/10/2007)
  49. J. Riley, M. Hassan, V. Chernomordik, and A.H. Gandjbakhche, "Choice of data types in time resolved fluorescence enhanced diffuse optical tomography”, 2007, Medical Physics 34(12), 4890-4900
  50. V. Chernomordik, M. Hassan, F. Amyot, J. Riley, and A. Gandjbakhche, “Use of scaling relations to extract intrinsic fluorescence lifetime of targets embedded in turbid media”, 2008, J. Biomed. Opt., Vol. 13, 024025
  51. A.R. Small, A. Neagu, F. Amyot, D. Sackett, V. Chernomordik, and A. Gandjbakhche, “Spatial distribution of VEGF isoforms and chemotactic signals in the vicinity of a tumor”, 2008, J. Theor. Biol. 252(4), 593-607
  52. S.B. Lee, M. Hassan, R. Fisher, O. Chertov, V. Chernomordik, G. Kramer-Marek, A. Gandjbakhche, and J. Capala, “Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging”, 2008, Clin. Cancer. Res. 14: 3840-3849
  53. J. M. Kainerstorfer, F. Amyot, S.G. Demos, M. Hassan, V. Chernomordik, C.K.Hitzenberger, A. H. Gandjbakhche and J. D. Riley, “Direct Curvature Correction for Non-Contact Imaging Modalities –Applied to Multi-Spectral Imaging”, 2010, J. Biomed. Opt., 15(4), 046013
  54. J. M. Kainerstorfer, M. Ehler, F. Amyot, M. Hassan, S. G. Demos, V. Chernomordik, C. K. Hitzenberger, A. H. Gandjbakhche, and J. D. Riley, “Principal Component Analysis of Multi Spectral Data for Near Real Time Skin Chromophore Mapping”, 2010, J. Biomed. Opt., 15(4), 046007
  55. V. Chernomordik, A. H. Gandjbakhche, M. Hassan, S. Pajevic, and G. H. Weiss, “A CTRW-based model of time-resolved fluorescence lifetime imaging in a turbid medium”, 2010, Optics Communications, 283, 4832-­4839
  56. V. Chernomordik, A. H. Gandjbakhche, G. H. Weiss, and L. Dagdug, “Effects of anisotropy of the turbid media on the photon penetration depth”, 2010, J. of Modern Optics, 57(20):2048-2053
  57. V. Chernomordik, M. Hassan, S. B. Lee, R. Zielinski, A.H. Gandjbakhche, and J. Capala, “Quantitative analysis of HER2 receptors expression in vivo by near-infrared optical imaging”, 2010, Molecular Imaging, 9(4):192-200
  58. J.M. Kainerstorfer, J.D. Riley, M. Ehler, L. Najafizadeh, F. Amyot, M. Hassan, R. Pursley, S.G. Demos, V. Chernomordik, M. Pircher, P. D. Smith, C. K. Hitzenberger, and A. H. Gandjbakhche, “Quantitative principal component model for skin chromophore mapping using multi spectral images and spatial priors”, 2011, Biomedical Optics Express, 2(5):1040-1058
  59. M. Hassan*, V. Chernomordik*, R. Zielinski*, Y. Ardeshirpour, J. Capala, and A.H. Gandjbakhche, “In Vivo Method to Monitor Changes in HER2 Expression Using Near-Infrared Fluorescence Imaging”, Mol Imaging 11(3):177-86. (authors, marked *, contributed equally)
  60. Y. Ardeshirpour, V. Chernomordik , J. Capala, M. Hassan , R. Zielinski, G. Griffiths, S. Achilefu, P. Smith, and A.H. Gandjbakhche, “Using In-vivo Fluorescence Imaging in Personalized Cancer Diagnostics and Therapy, an Image and Treat Paradigm,” Technology in Cancer Research and Treatment, 2011, 10(6):549-560
  61. J. D. Riley, F. Amyot, T. Pohida, R. Pursley, Y. Ardeshirpour, J.M. Kainerstorfer, L. Najafizadeh, V. Chernomordik, P. Smith, J. Smirniotopoulos, E.M. Wassermann, and A.H. Gandjbakhche, "A hematoma detector – a practical application of instrumental motion as signal in near infra-red imaging", Biomedical Optics Express, 2012, 3(1):192-205
  62. Y. Ardeshirpour, V. Chernomordik, R. Zielinski, J. Capala, G. Griffiths, O. Vasalatiy, A.V. Smirnov, J.R. Knutson, I. Lyakhov, S. Achilefu, A. Gandjbakhche, and M. Hassan, “In vivo Fluorescence Lifetime Imaging Monitors Binding of Specific Probes to Cancer Biomarkers”, PLoS ONE, 7(2):e31881, 2012, February 23
  63. F. Amyot, T. Zimmermann, J. Riley, J.M. Kainerstorfer, L. Najafizadeh, V. Chernomordik, E. Mooshagian, F. Krueger; E.M. Wassermann, and A.H. Gandjbakhche, “Normative database of judgment of complexity task with functional near infrared spectroscopy - Application for TBI”, Neuroimage. 2012 Jan 28; 60(2):879-883.

Book Chapters:

  1. M. Hassan, V, Chernomordik, A. Vogel, D. Hattery, I. Gannot, R. Little, R. Yarchoan, and Amir Gandjbakhche,“Infrared imaging for tissue characterization and function”, in Chapter 30 “The Medical Devices and Systems”, the Biomedical Engineering Handbook, 3rd edition, Editor J. D. Bronzino, Taylor & Francis, 2006
  2. Hassan M, Chernomordik V., Vogel A., Hattery D., Gannot I., Yarchoan R. and Gandjbakhche A. “Infrared imaging for functional monitoring of disease processes”. In Chapter 16 “Medical Infrared Imaging”, Editors: Nicholas Diakides and Joseph Bronzino. CRC press, Florida, USA, 2007.

US Patent

  • A. Gandjbakhche, D. Hattery, P. Smith, J. Mulshine, E. Hawk, and V. Chernomordik, “PROBE USING DIFFUSE-REFLECTANCE SPECTROSCOPY, ” US Patent 20050256383 , 2002
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