News & Updates

Research conducted at NICHD and at NICHD-funded institutions continues to bring us closer to fulfilling our vision of ensuring healthy pregnancies, healthy children, and healthy and optimal lives.

Children and teens injured by a firearm were 50% more likely to be diagnosed with a mental health disorder in the year after the injury, compared to children and teens injured in a motor vehicle crash, according to an analysis of medical records funded by the National Institutes of Health. The findings suggest that firearm injuries may increase the risk for mental health disorders more than other kinds of traumatic injuries and that children injured by firearms may benefit from mental health screening.

Cellular metabolism helps govern the speed of embryonic development, according to an NIH funded study. Insights from the work help explain why different animal species develop at distinct rates. The findings also suggest the potential to manipulate developmental rates at the cellular level.

Read about NICHD’s research findings and activities from 2022.

Amyloid plaques—protein clumps that are one of the hallmarks of Alzheimer’s disease—occur at roughly the same level in the brains of people with Down syndrome who have Alzheimer’s as they do in people with forms of hereditary, early-onset Alzheimer’s, according to research funded by the National Institutes of Health. Based on the largest study of its kind to date, the findings suggest that individuals with Alzheimer’s and Down syndrome may benefit from participating in studies on Alzheimer’s therapies aimed at slowing formation of amyloid plaques.

What defines eating for health? Clearly, there is no one-size-fits-all healthy diet. The emerging field of precision nutrition aims to deliver personalized dietary recommendations to optimize health and quality of life based on an individual’s genetics, gut microbes, and other biological, lifestyle, environmental, and social factors.

Researchers at the National Institutes of Health believe they have discovered how influenza viruses open a hole in the cell membrane to inject genetic material into the cell. The findings may inform the development of new technologies to combat infectious microbes and to insert medications, genes, and proteins into cells to treat diseases.

Study finds that a second operation benefits the small subset of women who choose reoperation for recurring symptoms.

A program that combines computer-based and driving simulator training may reduce the proportion of crashes and near crashes among teens with attention-deficit/hyperactivity disorder (ADHD), according to a small study funded by the National Institutes of Health. Teens who took the training, which aims to reduce the number of long glances away from the roadway, had a nearly 40% lower risk for crash or near crash, compared to a similar group who did not undergo the training.

Exposure to a chemical found in a wide variety of consumer products may trigger the growth of uterine fibroid cells and delay the rate at which they die, suggests a study funded by the National Institutes of Health. The study provides a potential explanation for why women exposed to industrial chemicals known as phthalates—found in personal care products, food packaging, and medical products—have higher rates of fibroid tumors than other women. The findings may also inform future strategies to prevent or treat fibroids.

A bacterial species that causes chorioamnionitis—an infection of the placenta and fetal membranes that often leads to preterm birth—relies on a gene for metal tolerance to hijack immune cells, suggests a study in mice funded by the National Institutes of Health. The findings indicate that strategies to target the gene and its products could eliminate one of the most common causes of preterm birth.

Researchers supported by the National Institutes of Health are launching a large study to evaluate a single dose of intravenous iron to treat women experiencing anemia after giving birth. The study will enroll nearly 5,000 women in Bangladesh, India, Pakistan, the Democratic Republic of Congo, Kenya, Zambia and Guatemala.

A safe, highly effective, reversible method of male contraception would fill an important public health need. Additionally, multipurpose prevention technologies (MPTs)—products that prevent both pregnancy and sexually transmitted infections—would increase sexual and reproductive health options for both women and men. NICHD supports a broad range of contraceptive research, including efforts to develop male contraceptives and MPTs.

Compared to giving birth in 2019, giving birth in 2020 during the early stages of the pandemic was not associated with a higher risk of maternal death or a serious complication of pregnancy, suggests a study funded by the National Institutes of Health.

Malaria infection of the placenta may reduce the amount of glucose that passes to the fetus, according to an NIH-funded study. The research involves a placenta on a chip model—a laboratory device incorporating placental tissue to simulate the interface between maternal blood and the outermost part of the placenta. The findings offer insight into how placental malaria may deprive the fetus of an essential nutrient and may inform the development of strategies to prevent or treat the condition.

A large international study has confirmed the findings of a previous U.S. study that linked COVID-19 vaccination with an average increase in menstrual cycle length of less than one day. The increase was not associated with any change in the number of days of menses (days of bleeding). Funded by the National Institutes of Health, the new study included data from nearly 20,000 people from Canada, the United Kingdom, the United States, Europe and other parts of the world who received any of nine different vaccines. For most study participants, the increase resolved in the cycle following vaccination.

Steroid treatment before birth appears to improve survival and reduce complications among extremely preterm infants, according to a study funded by the National Institutes of Health. Antenatal steroid therapy, given to women at risk of preterm delivery, causes the fetal lungs to mature and has been shown to improve survival and reduce complications among infants born from 24 to 34 weeks of pregnancy. However, previous studies of the treatment for infants born between the 22nd and 23rd week—those at greatest risk for death and disability—were inconclusive.

Psychological distress before COVID-19 infection—feeling stressed, depressed, anxious, worried, or lonely—may raise the risk for long COVID, suggests a study funded by the National Institutes of Health.

Eight years ago, NIH announced a collaboration with the Bill & Melinda Gates Foundation to develop solutions for a variety of global health challenges. Learn how NICHD research is supporting this goal.

U.S. rates of pregnancy-associated homicide—deaths that occur among women who are pregnant or had been pregnant within one year—rose in 2020 during the COVID-19 pandemic, according to a recent NICHD-funded study.