A small study by researchers at the National Institutes of Health suggests that mutations in the gene CABLES1 may lead to Cushing syndrome, a rare disorder in which the body overproduces the stress hormone cortisol. The study appears online in Endocrine-Related Cancer.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
NICHD scientists identify molecule that may help control sleep and wake cycles
A molecule may work with the hormone melatonin to regulate 24-hour changes in metabolism, including sleep and wake cycles, according to researchers at the National Institutes of Health and other institutions.
Medical imaging device developed by NIH researchers awarded U.S. patent
A device that calibrates MRI scanners to improve image and data quality has received U.S. patent approval. The inventors are researchers at NICHD and the National Institute of Biomedical Imaging and Bioengineering.
NIH researchers identify key regulator of fetal growth in mice
NICHD researchers show that proteins known for silencing viral genes left over from ancient infections can also play an essential role in fetal and placental development.
Cell particles may help spread HIV infection, NIH study suggests
HIV appears to enlist the aid of nano-sized structures released by infected cells to infect new cells, according to a study by researchers at NICHD.
NIH researchers trace origin of blood-brain barrier ‘sentry cells’
National Institutes of Health researchers studying zebrafish have determined that a population of cells that protect the brain against diseases and harmful substances are not immune cells, as had previously been thought, but instead likely arise from the lining of the circulatory system.
NICHD scientists identify proteins involved in cells’ energy production
Energy production in mitochondria—structures within cells that produce energy from oxygen and nutrients—relies on a group of proteins previously not linked to this process, according to a study by NICHD researchers.
NICHD scientists identify mechanism for lysosome transportation within neurons
Uneven distribution of lysosomes, the structures that break down unneeded or worn-out cell parts, can impair the shape and function of neurons, according to a study led by NICHD researchers.
NICHD scientists identify in mice a potential mechanism of lysosomal storage disorders
The misdelivery of proteins to lysosomes, the structures within cells that break down unneeded or worn-out proteins, fats, carbohydrates and cell parts, appears to underlie a family of rare neurodegenerative diseases.
NICHD scientists decipher how group of proteins regulate immune cell development in mice
Immune system proteins called Themis are essential for helping two major types of infection-fighting immune cells mature, according to two studies led by researchers at NICHD.
Cigarette smoking during pregnancy linked to changes in baby’s immune system
Infants whose mothers smoked cigarettes throughout pregnancy had higher levels of an inflammation marker called interleukin-8 at birth, according to an NICHD study.
Some women with PCOS may have adrenal disorder, NIH researchers suggest
A subgroup of women with polycystic ovary syndrome (PCOS), a leading cause of infertility, may produce excess adrenal hormones, according to an early study by researchers at the National Institutes of Health and other institutions.
Proper maternal folate level may reduce child obesity risk
Proper maternal folate levels during pregnancy may protect children from a future risk of obesity, especially those born to obese mothers, according to a study funded by NICHD.
Rare cancers may masquerade as ADHD in children, NIH researchers suggest
Rare tumors called pheochromocytomas and paragangliomas may cause the same symptoms as attention deficit hyperactivity disorder (ADHD) in children, leading to inappropriate treatment that could worsen their symptoms and potentially endanger their health. That’s the conclusion of a new study by National Institutes of Health researchers who evaluated a group of pediatric patients diagnosed with the tumors.
Children with Cushing syndrome may have higher suicide risk
Children with Cushing syndrome may be at higher risk for suicide as well as for depression, anxiety and other mental health conditions long after their disease has been successfully treated, according to a study by researchers at the National Institutes of Health.
NICHD researchers identify cause of rare disease, Smith-Lemli-Opitz syndrome
Smith-Lemli-Opitz syndrome, a rare genetic disease that disrupts the nervous system and can lead to microcephaly and other brain defects, appears to result from a buildup of a cholesterol precursor, according to a new study by NICHD researchers.
NIH researchers uncover how neurons die in Niemann-Pick disease type C1
The loss of neurons that is a hallmark of Niemann-Pick disease type C1 (NPC1) appears to result from a cell death process called necroptosis, according to a new study from the National Institutes of Health (NIH).
Prenatal exposure to marijuana may disrupt fetal brain development, mouse study suggests
Fetal mice exposed in the uterus to delta-9-tetrahydrocannabinol (THC), marijuana’s primary psychoactive ingredient, lose a key subset of neurons, according to a new study by NICHD researchers.
NICHD Invites Researchers to Share Their Data through Online Resource
Researchers may now add data from NICHD-funded studies directly to the NICHD Data and Specimen Hub (DASH).
Spotlight: NICHD Needs Your Input for the All of Us Research Program
NICHD needs your input for NIH’s All of Us program.
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