News

The experimental drug TEMPOL prevents viral replication by targeting the SARS-CoV-2 helicase, in addition to the virus’ replicase, according to a new NICHD study.

Delivery of the gene for neurotrophic factor-α1 directly into the hippocampus of the brain prevents neurodegeneration and memory loss in a mouse model of Alzheimer’s disease.

The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.

A gel made from the seeds of a South American palm tree entraps SARS-CoV-2 and the protein the virus uses to enter cells, preventing the virus from infecting cells in laboratory cultures, a National Institutes of Health study has found. The findings raise the possibility of future studies to determine if the gel could be incorporated into masks and filters to reduce airborne spread of SARS-CoV-2.

Findings may aid design of targeted drug delivery into the brain and central nervous system.

A research team including NICHD scientists has developed a potential gene therapy for hereditary spastic paraplegia 50, a rare childhood-onset neurodegenerative disorder that leads to developmental delays, cognitive impairment, and eventual paralysis.

Dr. Veronica Gomez-Lobo, director of Pediatric and Adolescent Gynecology at NICHD, began her career as a clinician focused on caring for underserved populations. Taking advantage of interesting opportunities led her to become involved in medical education, and later, in scientific research.

Cells lining the umbilical vein secrete a newly discovered extracellular vesicle—a tiny, balloon-like structure that influences other cells—suggests a study by researchers at the National Institutes of Health. The findings may have implications for understanding fetal development and may inform strategies to use extracellular vesicles to deliver drugs and other therapies.

Researchers at NIH have discovered that mutations in the gene SPIN4 cause a rare overgrowth disorder in people.

A biomarker used to detect a rare neurodegenerative disorder of cholesterol metabolism, Niemann-Pick disease type C1 (NPC1), may also be useful for diagnosing another class of rare diseases known as congenital disorders of glycosylation (CDG), suggests a study by researchers at the National Institutes of Health.

The Division of Intramural Research provides fundamental knowledge about the nature and behavior of living systems through basic, clinical, and population-based research.

Christopher McBain, Ph.D., scientific director of the Division of Intramural Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), has been elected as a fellow of the American Association for the Advancement of Science (AAAS).

Christopher McBain, Ph.D., has been appointed scientific director and director of the Division of Intramural Research at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health.

Research conducted at NICHD and at NICHD-funded institutions continues to bring us closer to fulfilling our vision of ensuring healthy pregnancies, healthy children, and healthy and optimal lives.

Mouse study improves understanding of events leading to preterm labor and birth

Read about NICHD’s research findings and activities from 2022.

Reducing levels of the protein WAPL may partially correct disease traits caused by a deficiency of NIPBL, a protein with the opposite function, suggests a mouse study by NICHD scientists. The findings suggest the importance of striking a proper balance between NIPBL and WAPL activities and improve understanding of the mechanisms underlying the rare developmental disorder Cornelia de Lange syndrome.

A safe, highly effective, reversible method of male contraception would fill an important public health need. Additionally, multipurpose prevention technologies (MPTs)—products that prevent both pregnancy and sexually transmitted infections—would increase sexual and reproductive health options for both women and men. NICHD supports a broad range of contraceptive research, including efforts to develop male contraceptives and MPTs.

Exposure to caffeine in the womb, even in small amounts, may lead to shorter height in childhood, suggests an analysis by NICHD researchers. Children of women with low caffeine intake during pregnancy were slightly shorter than their peers born to women who consumed no caffeine while pregnant. The gaps in height widened between ages 4 and 8 years.