The Human Placenta Project: Placental Structure and Function in Real Time

May 27–28, 2014

Sponsor/Co-Sponsor(s)

NICHD

Agenda

May 27, 2014

7:30 a.m.	Goals for Human Placenta Project (HPP) and Workshop Alan Guttmacher and Cathy Spong


7:40 a.m.	Introductions Alan Guttmacher and Cathy Spong


8:00 a.m.	Overview of Placental Formation and Structure (PDF - 3.2 MB) Graham Burton


8:45 a.m.	Maternal Placental Syndromes: Conditions Due to Placental Abnormalities (PDF - 1.9 MB) George Saade


9:30 a.m.	Current Methods for Assessing Placental Development and Function and Their Limitations (PDF - 3 MB) Yoel Sadovsky


10:15 a.m.	Break


10:30 a.m.	Panel Discussion: Shared Pathophysiological Processes That May Be Assessed Using Knowledge and Technologies From Other Fields (6-Minute Presentations on the Specific Dysfunction and Its Relevance, Followed by Discussion) Anatomy and Tissue Structure: Susan Fisher (PDF - 5.9 MB) Utero-Placental Perfusion: Kathleen Schmainda (PDF - 2.2 MB) Tissue and Cellular Metabolism: Nick Illsley (PDF - 735 KB) Immunology, Inflammation: Gil Mor (PDF - 900 KB)


11:15 a.m.	Lunch


12:00 p.m.	Breakout Sessions: Shared Pathophysiological Processes that may be Assessed Using Knowledge and Technologies from Other Fields Breakout 1: Anatomy and Tissue Structure: Led by Susan Fisher Breakout 2: Utero-Placental Perfusion: Led by Kathleen Schmainda Breakout 3: Tissue and Cellular Metabolism (e.g., Nutrient Transfer, Biochemistry, -omics): Led by Nick Illsley Breakout 4: Immunology, Inflammation (e.g., Graft vs. Host Interactions): Led by Gil Mor Charge to Breakout Sessions: What functions are important to evaluate in real time? What are the current state-of-the-art approaches in obstetrics for assessing these processes? How are these processes assessed in other fields? What technologies might be applicable to HPP? What technologies need to be developed to address the pathophysiologic process?


2:00 p.m.	Breakout Groups Report Back, Followed by Discussion


3:30 p.m.	Panel Presentation: Applying Technologies To Study the Placenta in Real Time: Currently Utilized Imaging Technologies—How To Optimize or Further Their Use (6-Minute Presentations, Followed by Discussion) Ultrasound, Dopple: Alfred Abuhamad (PDF - 1.1 MB) MRI, fMRI, MR angiography: John Sled (PDF - 737 KB)


4:00-6:00 p.m.	Breakout Sessions: Currently Utilized Imaging Technologies—How To Optimize or Further Their Use Breakout 1: Ultrasound: Led by Alfred Abuhamad Breakout 2: MRI: Led by John Sled Charge to Breakout Groups: What are the "adjacent possible" to application in obstetrics for each technology? What technologies might be applicable to HPP? What technologies need to be developed to address the pathophysiologic process? Describe what needs to be done to develop/stimulate/ encourage/facilitate this area to move forward to understand human placental structure and function in real time. Are there initial steps that must first occur (e.g., technologies to develop)?


6:00 p.m.	Adjourn

May 28, 2014


8:00 a.m.	Breakout Groups Report Back: Currently Utilized Imaging Technologies—How To Optimize or Further Their Use


9:00 a.m.	Panel Presentation: Emerging or Potentially Promising Technologies—How To Develop and/or Optimize Their Use (6-Minute Presentations on the Technology, Followed by Discussion) Nanotechnology: Erik Rytting (PDF - 1.73 MB) Biochemical Techniques: Carolyn Ott (PDF - 864 KB) High-Throughput –omics: Diana Bianchi (PDF - 580 KB) Systems Science, Computational Biology: Brian Cox Data Management: Peter Basser


10:15 a.m.	Breakout Sessions: Emerging or Potentially Promising Technologies—How To Develop and/or Optimize Their Use Breakout 1: Nanotechnology (e.g., Nanorobots, Intravascular Sensors): Led by Erik Rytting Breakout 2: Biochemical Techniques: Led by Carolyn Ott Breakout 3: High-Throughput –omics: Led by Diana Bianchi Breakout 4: Systems Science, Computational Biology: Led by Brian Cox Breakout 5: Data Management (e.g., Sharing, Manipulation, Reconstruction): Led by Peter Basser Charge to Breakout Groups: What are the "adjacent possible" to application in obstetrics for each technology? What technologies might be applicable to HPP? What technologies need to be developed to address the pathophysiologic process? Describe what needs to be done to develop/stimulate/ encourage/facilitate this area to move forward to understand human placental structure and function in real time. Are there initial steps that must first occur (e.g., technologies to develop)?


12:30 p.m.	Lunch



1:30 p.m.	Breakout Groups Report Back, Identifying More Specific Targets for HPP Phase I


3:15 p.m.	Design and Develop the HPP "Roadmap" Alan Guttmacher and Cathy Spong


4:15 p.m.	Wrap Up and Next Steps Alan Guttmacher


4:30 p.m.	Adjourn

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