Prevention And Treatment through a Comprehensive Care Continuum for HIV-affected Adolescents in Resource Constrained Settings (PATC3H)

In 2022 and 2023, NIH published new Requests for Applications (RFAs) that will form the PATC³H Implementation Science Network (PATC³H-IN): RFA-HD-23-013: PATC³H-IN: Clinical Research Centers (UG1 Clinical Trial Optional) and RFA-HD-24-009: PATC³H-IN: Implementation Science Coordinating Center (UM2 Clinical Trial Optional).

Please note: RFA-HD-24-009 for a PATC³H-IN Implementation Science Coordinating Center has an application due date of December 6, 2023, and an optional Letter of Intent due date of November 6, 2023.

The PATC³H-IN Network Frequently Asked Questions page offers additional information about these RFAs as well as accompanying informational slides about this new network.

• Overview
• Current Studies
• More Information

Overview

Formed in 2018, PATC³H is a consortium of research teams that conducts clinical research and evaluations of a variety of combination interventions aimed at the individual, family, community, structural and education, and health systems levels, to improve health outcomes among adolescents with or at risk for HIV.

PATC³H’s primary goal is to generate the needed scientific innovation that will yield effective public health interventions for 10- to 24-year-olds (with emphasis on those age 20 or younger) affected by HIV in resource-limited settings of Brazil and sub-Saharan Africa. The program explores needs and interventions that may help reduce the HIV incidence rates among adolescents, while maximizing the impact of research in adolescent prevention and care for youth with HIV within these countries.

PATC³H is funded through the NICHD Maternal and Pediatric Infectious Disease Branch, the National Institute on Minority Health and Health Disparities, the Office of Behavioral and Social Sciences Research, and the Office of AIDS Research.

Current Studies

PATC³H study programs include the following:

• Brilho e Transcender (BeT): Intervention to reduce HIV prevention and care disparities among young transwomen (Rio De Janeiro, Brazil)
• CombinADO: Combination intervention strategy to improve health outcomes for adolescents (Zambezia, Mozambique)
• Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes (Western Kenya)
• Intensive Combination Approach to Rollback the Epidemic (iCARE) in Nigerian Adolescents (Ibadan, Nigeria)
• SHIELD & IWC: Support for HIV Integrated Education, Linkages to Care, and Destigmatization & Integrated Wellness Care (Zambia)
• Innovative Tools to Expand Youth-Friendly HIV Self-Testing (ITEST)(Nigeria)
• Multilevel Comprehensive HIV Prevention for South African Adolescent Girls and Young Women (IMARA)
• Strategic antiretroviral therapy and HIV testing for youth in rural Africa (SEARCH-Youth) (Uganda and Kenya)

More Information

• PATC³H Website (maintained by Westat)
• NICHD Contacts: Franklin Yates and Sonia Lee

Need data? PATC³H studies are now available in NICHD’s Data and Specimen Hub (DASH). Browse studies and request data for your research.