In 2022 and 2023, NIH published new Requests for Applications (RFAs) that form the PATC3H Implementation Science Network (PATC3H-IN): RFA-HD-23-013: PATC3H-IN: Clinical Research Centers (UG1 Clinical Trial Optional) and RFA-HD-24-009: PATC3H-IN: Implementation Science Coordinating Center (UM2 Clinical Trial Optional).
The PATC3H-IN Network Frequently Asked Questions page offers additional information about this clinical research network.
Overview
Formed in 2018, PATC3H was a consortium of research teams 
that conducted clinical research and evaluations of a variety of combination interventions aimed at the individual, family, community, structural and education, and health systems levels to improve health outcomes among adolescents with or at risk for HIV.
PATC3H’s primary goal was to generate the needed scientific innovation that will yield effective public health interventions for 10- to 24-year-olds (with emphasis on those age 20 or younger) affected by HIV in resource-limited settings globally. The program explored needs and interventions that helped reduce the HIV incidence rates among adolescents, while maximizing the impact of research in adolescent prevention and care for youth with HIV within these countries.
PATC3H-IN (Implementation Science Network), launched in 2023, is a successor to PATC3H with newly established Clinical Research Centers for adolescent HIV prevention and treatment research in sub-Saharan Africa that each have robust Implementation Science aims. It is further complemented by an Implementation Science Coordinating Center designed to support three core elements of the network: 1. research education and capacity building across PATC3H-IN; 2. infrastructure for dissemination of findings and stakeholder engagement; and 3. advanced statistical modeling support and translational projects.
PATC3H-IN is funded through the NICHD Maternal and Pediatric Infectious Disease Branch, the National Institute on Minority Health and Health Disparities, the National Institute of Mental Health, the National Institute on Drug Abuse, and the Fogarty International Center.
Current Studies
PATC3H-IN Clinical Research Centers include the following:
- ATTUNE: Evaluation of Long Acting Injectable and Teen clubs in adolescents (South Africa)
- iCARE Plus: Intensive Combination Approach to Rollback the HIV Epidemic in Nigerian Youth Plus Effectiveness/Implementation Hybrid Study (Nigeria)
- MUJHU: Implementation Science to Understand and Design Stakeholder Informed Innovative Interventions to Improve Adolescent and Youth HIV Prevention and Care Continuums in Rural and Urban Uganda (Uganda)
- MWOTAJI: Making women's options for HIV prevention in Tanzania accessible and joining implementation science capacity building (Tanzania)
- RISE: Resilient HIV Implementation Science with Young Men using Evidence Clinical Research Center (Nigeria, Kenya, Malawi, Zambia)
- S-ITEST: Sustaining Innovative Tools to Expand Youth-Friendly HIV Self-Testing (Nigeria)
- VS4A: VITAL Start (Video-Intervention to Inspire Treatment Adherence for Life) for Adolescents, a video intervention to improve retention and adherence to ART among adolescents living with HIV (Malawi)
- ZAIMARA: Zambian Informed Motivated Aware and Responsible Adolescents and Adults (Zambia)
PATC3H-IN Implementation Science Coordinating Center:
- INSPIRE: Innovative Network on the Science and Practice of Implementation, Research, and Engagement Center
More Information
- PATC3H Website (maintained by Westat)
- NICHD Contacts: Franklin Yates and Sonia Lee
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