News & Updates

A healthy diet around the time of conception through the second trimester may reduce the risk of several common pregnancy complications, suggests a study by researchers at the National Institutes of Health.

NICHD Director Dr. Diana Bianchi is joined by NIH Office of Research on Women’s Health Director Dr. Janine Clayton in assessing the growing maternal health crisis in the United States and describing NIH’s efforts to address it.

Current vaccines to prevent COVID-19 are highly effective in producing antibodies in pregnant women, resulting in more antibodies than what is generated from a natural SARS-CoV-2 virus infection, according to a study funded by the National Institutes of Health. Moreover, antibodies produced after vaccination are present in breastmilk and travel across the placenta, indicating that vaccination during pregnancy will also confer immunity to newborns.

For many COVID-19 patients, full recovery remains elusive even long after they should feel “better.” NIH recently announced research opportunities to understand COVID-19 long haulers, who have what researchers now refer to as Post-acute sequelae of SARS-CoV-2 infection (PASC). NICHD joins these opportunities while remaining focused on PASC patients within our audiences of interest—pregnant and lactating people, children, and those with disabilities.

A new study funded by the National Institutes of Health will evaluate the effects of remdesivir in pregnant women who have been prescribed the drug to treat COVID-19. The study, which will be conducted at 17 sites in the continental United States and Puerto Rico, aims to determine how pregnant women metabolize the drug and whether there are any potential side effects.

Pregnant women need to be protected through research rather than from research, the authors contend.

As the COVID-19 pandemic persists, SARS-CoV-2 vaccines offer the potential to halt the spread of the virus. Yet, we know very little about the effectiveness and safety of the vaccines during pregnancy.

A hormone-releasing intrauterine device (IUD) appears to be as effective at emergency contraception as a copper IUD, suggests a study funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The hormone-releasing IUD contains levonorgestrel, a synthetic form of the reproductive hormone progesterone. Compared to the copper IUD, the levonorgestrel IUD has been shown to reduce heavy bleeding and menstrual discomfort.

NIH-funded study suggests mother-to-infant transmission appears to be rare

Increased stress may interfere with adjustment to new motherhood, mother-infant bonding

Pregnant women who are infected with SARS-CoV-2, the virus that causes COVID-19, during the third trimester are unlikely to pass the infection to their newborns, suggests an NIH-funded study.

Vegetarian diets during pregnancy are associated with small infant birth weight, but not a higher risk preterm birth or other medical complications, suggests a National Institutes of Health study.

Women with asthma are more likely than normal to gain weight during pregnancy and to retain weight 3 months after giving birth, suggests a National Institutes of Health study. On average, women with asthma gained 3.1 kg (just under 7 lbs) more after a full-term pregnancy than women without asthma. Among women with asthma, weight gain was greater with obesity. Weight gain was also greater with more severe asthma and with asthma triggered by exercise. The study authors suggest that their findings underscore the importance of pre-pregnancy counseling for women with asthma on the need to achieve and maintain a healthy body weight.

National Institutes of Health study suggests women with mood disorders, gestatational diabetes may have a higher risk.

Negative pressure wound therapy (NPWT) does not appear to lower the risk of infection for obese women after cesarean delivery, suggests a study funded by the National Institutes of Health. The treatment involves placing a low-pressure pump over a closed surgical wound to create negative air pressure. Earlier studies had suggested that NPWT might reduce infection risk and promote healing after surgery. The study of more than 1,600 obese women found no significant difference in infection between women treated with NPWT and those receiving standard wound dressing.

The study of approximately 16,000 pregnant women will continue 12 months after childbirth and compare maternal, fetal and newborn outcomes of participants infected with the virus to those of pregnant women who have not.

Scoring system developed by NIH-funded researchers standardizes patient data to aid research, surveillance and improvement initiatives.

NICHD has supported gynecologic and reproductive health research for decades. Learn more about its leading role in menstruation research.

The placental membranes that contain the fetus and amniotic fluid lack the messenger RNA (mRNA) molecule required to manufacture the ACE2 receptor, the main cell surface receptor used by the SARS-CoV-2 virus to cause infection, according to a study by researchers at the National Institutes of Health.

In a study of mice, NIH-funded researchers have developed a prototype technique for shrinking uterine fibroids—sometimes painful, noncancerous tumors that form in the uterus. The method involves encasing a tumor-killing drug in nano-sized spheres called liposomes and delivering them directly to the fibroids through the bloodstream. The findings set the stage for studies to determine if the method is safe and effective for treating fibroids in people.