News

In a study of mice, researchers have slowed an immune system attack on the ovaries. The mice developed a disorder resembling primary ovarian insufficiency (POI), a menopause-like condition that affects women under the age of 40, sometimes years or even decades before normal menopause. The study was conducted by scientists at the National Institutes of Health and the University of California, San Francisco (UCSF).

The 2010 DIR Annual Report illustrates the impressive accomplishments that result when dozens of PIs, more than 350 trainees, and approximately 1,200 staff all work toward the same goal of improving human health.

Researchers funded by the National Institutes of Health have identified a key step in the establishment of a pregnancy. Their discovery shows how the hormone progesterone suppresses the growth of the uterus's lining so that a fertilized egg can implant in the uterus.

NICHD Director Alan E. Guttmacher, M.D., initiated the NICHD Director’s Lecture Series as a way to showcase cutting-edge science relevant to the Institute’s mission. The forum also enables staff and other attendees to interact with other nationally recognized scientists.

Young women with the menopause-like condition, primary ovarian insufficiency, are much more likely than other women to experience depression at some point during their lives, according to a study from the National Institutes of Health. The finding suggests that all women diagnosed with the condition should be evaluated for depression.

A study by researchers at the National Institutes of Health and the University of Oxford supports the widespread belief that stress may reduce a woman's chance of becoming pregnant. The study is the first of its kind to document, among women without a history of fertility problems, an association between high levels of a substance indicative of stress and a reduced chance of becoming pregnant.

Researchers supported by the National Institutes of Health have for the first time activated mouse egg cells at the earliest stage of their development and brought them to maturity. In a related experiment, the researchers replicated the finding by also bringing human eggs to maturity in the laboratory.

Millions of Americans with reproductive health disorders stand to benefit from new research funded by the National Institutes of Health. With funds from the American Recovery and Reinvestment Act, the National Institutes of Health today announced grants totaling nearly $60 million for research into disorders that impair fertility, cut short a woman's reproductive years, and often cause intense pain.

The Division’s research programs address topics ranging from molecular and cellular biology, genetics, and endocrine and genetic disorders, to physical biology, neurosciences, immunology, reproduction, and behavioral research. Its projects are organized around the theme of the orchestration of life by molecular messengers.

Researchers funded in part by the National Institutes of Health have discovered how to transform human embryonic stem cells into germ cells, the embryonic cells that ultimately give rise to sperm and eggs. The advance will allow researchers to observe human germ cells--previously inaccessible--in laboratory dishes.

The National Institutes of Health has developed a research plan to advance the understanding of fragile X syndrome and its associated conditions, fragile X-associated tremor/ataxia syndrome and fragile X-associated primary ovarian insufficiency. Fragile X syndrome causes intellectual and developmental disabilities and results from a mutation in a gene on the X chromosome.

Researchers funded by the National Institutes of Health have completed a critical first step in the eventual development of a technique to retain fertility in women with cancer who require treatments that might otherwise make them unable to have children.

Researchers from the National Institutes of Health and other institutions have identified in mice two proteins essential for ovulation to take place.

A comprehensive plan to help health care professionals diagnose and treat primary ovarian insufficiency--a menopause-like condition affecting girls and young women that may occur years before normal menopause is expected--has been developed by a scientist at the National Institutes of Health.

NIH-sponsored researchers have discovered that women who have polycystic ovary syndrome (PCOS) are less likely to ovulate in response to a promising new drug treatment for the condition if they have a variation in a particular gene.

Metformin, a drug used to treat diabetes and thought to hold great promise at overcoming the infertility associated with polycystic ovary syndrome (PCOS), is less useful for helping women with the condition achieve pregnancy than is the standard treatment with the infertility drug clomiphene, report researchers in an NIH research network.

A team of researchers has determined that an enzyme in sperm is necessary for sperm movement. Mice bred to lack this enzyme produce sperm that cannot swim toward egg cells to fertilize them.

A team of researchers working with cells from mice has overcome a technical barrier and succeeded in growing sperm progenitor cells in laboratory culture.

A new study suggests that the conventional hormone therapies used to treat fibroid tumors are unlikely to produce much improvement and at best will only temporarily relieve symptoms. However, the study findings also suggest a strategy for developing a new, non-surgical treatment.

Fibroid tumors-the sometimes painful uterine growths affecting many American women-lack a key protein that plays a role in holding tissues together, according to a study by researchers from the Uniformed Services University of the Health Sciences (USUHS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health.