News

The NICHD continues to advance understanding of the effects of HIV/AIDS on infants, children, young people, women, and families.

An anti-HIV drug also discovered to stop the spread of the genital herpes virus does so by disabling a key DNA enzyme of the herpes virus, according to findings by researchers at the National Institutes of Health and other institutions.

In June, the world marked the 30th anniversary of the first case of what is now known as AIDS. The NICHD Spotlight, 30 Years of Milestones, highlighted some of the key moments in pediatric, adolescent, and maternal AIDS research.

As scientific understanding of the disease and its mechanisms continues to advance, we can find reasons to hope. Where once there were no treatment options, we now have multiple regimens that can help to manage the disease. Where once the disease spread seemingly without boundaries, we now have ways to prevent that spread. Researchers, health care providers, and communities around the world remain dedicated to preventing, treating, managing, and even curing AIDS.

Pregnant women who are unaware that they have HIV miss the chance for drug treatment that can benefit not only their own health, but could also prevent them from transmitting the virus to their infants. When HIV is not diagnosed until women go into labor, their infants are usually treated soon after birth with the anti HIV drug zidovudine (ZDV), to prevent the infants from becoming infected with the virus.

For children being treated for HIV in less developed countries, monitoring to predict the occurrence of serious HIV-related illnesses is most accurate if it includes a measure of HIV levels in the blood, according to a National Institutes of Health study conducted throughout Latin America.

On January 15, researchers funded by the National Institute of Allergy and Infectious Diseases (NIAID) and the NICHD launched the Promoting Maternal-Infant Survival Everywhere—or PROMISE—study.

This December, the NICHD joins the international community in recognizing the 21st annual AIDS Awareness Month. Research by the NICHD, several partner Institutes at NIH, and other organizations has helped change the outlook for those with HIV/AIDS in the United States and abroad. While it is good to reflect on how far we’ve come, the NICHD keeps its focus on the many challenges that remain for the future.

New guidelines to assist health care workers in preventing and treating the secondary infections that can afflict U.S. children exposed to, or infected with, HIV, were published by the National Institutes of Health and the Centers for Disease Control and Prevention.

The drug acyclovir has long been used to suppress outbreaks of oral and genital herpes. Herpes viruses change acyclovir to a form that prevents them from reproducing. Now, it appears that after acyclovir is altered by herpes viruses, it also interferes with the AIDS virus's ability to reproduce, report researchers from the National Institutes of Health and other institutions.

Each day, approximately 1,000 children—the majority of whom are newborns—become infected with HIV, according to the World Health Organization. HIV can be passed on during pregnancy or delivery, or even after the infant is born, through breastfeeding.

In many poor countries, mothers with HIV face a stark choice: to nurse their infants, and risk passing on HIV through their breast milk--or to formula feed, and deprive their infants of much of the natural immunity needed to protect against fatal diseases of early infancy. Now, two studies supported by the National Institutes of Health offer insights into preventing early death and HIV infection among breastfeeding infants of mothers with HIV in these countries.

An extended course of the antiretroviral drug nevirapine (NVP) helps the breastfeeding babies of HIV-infected mothers remain HIV-negative and live longer, according to several new studies presented at the 15th Conference on Retroviruses and Opportunistic Infections held in Boston from February 3-6.

Questions and Answers.

A woman's response to HIV treatment with drug combinations that contain nevirapine is improved if at least six months have passed after she received the drug as a single dose during labor to prevent passing HIV on to her child. (The response to treatment is measured by the reduction of HIV in the blood.)

Using hormonal contraception does not appear to increase women's overall risk of infection with the AIDS virus, report the authors of a large study commissioned by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health.

A single dose of the drug nevirapine given at the beginning of labor, when combined with a short course of the anti-HIV drug AZT (zidovudine), dramatically reduces a woman's chances of passing HIV on to her child, according to a study of Thai women funded in part by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health.

Multivitamin supplements containing high doses of the vitamin B complex, as well as vitamins C and E, given to HIV-infected women during pregnancy and for more than 5 years after they gave birth reduced the symptoms of AIDS, according to a study of Tanzanian women supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the John E. Fogarty International Center (FIC) for Advanced Study in the Health Sciences, both of the National Institutes of Health.

After four weeks of age, infants who breast feed from mothers infected with HIV continue to be at risk for infection with HIV for as long as they breastfeed, according to an analysis conducted and funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health.

A new study found no association between the use of an anti-HIV treatment that uses a combination of drugs during pregnancy and an increased risk of such birth complications as premature delivery, stillbirth, and low Apgar scores.