News

The Chief of NICHD's Perinatology Research Branch and his colleagues recently held a news briefing to describe a prototype treatment for an animal model of cerebral palsy. The researchers injected a bacterial toxin into the uteruses of pregnant rabbits. Like human patients with cerebral palsy, the baby rabbits developed a severe disability affecting their ability to move. When injected with nanoparticles carrying an anti-inflammatory drug, the baby rabbits recovered much of their movement ability.

Item of Interest: Video Presentation: Role of Research in Understanding, Preventing, and Treating Birth Defects

Asian women who consumed an average of 200 milligrams or more of caffeine a day--the equivalent of roughly two cups of coffee--had elevated estrogen levels when compared to women who consumed less, according to a study of reproductive age women by researchers at the National Institutes of Health and other institutions.

Vitamin D may help prevent hormonal changes that can lead to bone loss among those being treated for HIV with the drug tenofovir, according to the results of a National Institutes of Health network study of adolescents with HIV.

Researchers supported by the National Institutes of Health are undertaking a preliminary study to identify the early origins of heart disease among African-Americans. The new feasibility study will enroll children and grand children of participants taking part in the largest study of heart disease risk factors among African-American adults, the Jackson Heart Study (JHS), in Jackson, Miss.

The National Institutes of Health has joined with organizations interested in Down syndrome to form a consortium that will foster the exchange of information on biomedical and biobehavioral research on the chromosomal condition.

Recently, scientists in an NIH study reported that a surgical procedure to repair a common birth defect of the spine, if undertaken while a baby is still in the uterus, greatly reduces the need to divert, or shunt, fluid away from the brain, according to a study by the National Institutes of Health and four research institutions. The fetal surgical procedure also increases the chances that a child will be able to walk without crutches or other devices.

Spina bifida is a serious birth defect that affects about three to four out of every 10,000 live births in the United States. Spina bifida occurs when the spinal column—including the bones of the spine, muscles, and skin—does not develop or close completely around the spinal cord while a baby is growing in the womb.

A surgical procedure to repair a common birth defect of the spine, if undertaken while a baby is still in the uterus, greatly reduces the need to divert, or shunt, fluid away from the brain, according to a study by the National Institutes of Health and four research institutions.

Spina bifida, which literally means "split spine," is a complex birth defect that affects three to four out of every 10,000 live births. It occurs when part of the spinal column—which includes the spinal cord, associated nerves, spinal bones, and overlying muscle and skin—does not fully develop or close completely. The most frequent and severe form of spina bifida is called myelomeningocele, which is one of the most common birth defects causing lifelong disability.

Teens who were in high-quality child care settings as young children scored slightly higher on measures of academic and cognitive achievement and were slightly less likely to report acting-out behaviors than peers who were in lower-quality child care arrangements during their early years, according to the latest analysis of a long-running study funded by the National Institutes of Health.

Working with mice, a team of researchers has pinpointed the location of bone generating stem cells in the spine, at the ends of shins, and in other bones. The team also has identified factors that control the stem cells' growth. The research was conducted at the National Institutes of Health and other institutions.

Contrary to what researchers had previously believed, most young women and girls who experience a menopause-like condition called primary ovarian insufficiency still have immature eggs in their ovaries, according to a study by scientists at the National Institutes of Health.

Findings from an NICHD study indicate that, compared to women at normal weight, women who are obese before pregnancy are much more likely to have babies with congenital heart defects, problems with the heart’s structure that are present at birth.

The more obese a woman is when she becomes pregnant, the greater the likelihood that she will give birth to an infant with a congenital heart defect, according to a study conducted by researchers at the National Institutes of Health and the New York state Department of Health.

A gene that causes a fatal childhood brain disorder can also cause adults to develop peripheral neuropathy, a condition resulting in weakness and decreased sensation in the hands and limbs, according to a study by researchers at the National Institutes of Health and other institutions. The study is the first to show that different mutations in the same gene cause the two seemingly unrelated disorders.

Alan E. Guttmacher, M.D., is the new acting director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), one of the 27 institutes and centers that comprise the National Institutes of Health.

Researchers funded in part by the National Institutes of Health have discovered how to transform human embryonic stem cells into germ cells, the embryonic cells that ultimately give rise to sperm and eggs. The advance will allow researchers to observe human germ cells--previously inaccessible--in laboratory dishes.

Dr. Jennifer Lippincott-Schwartz recently joined a distinguished group of American and international scientists when she was elected to the Institute of Medicine (IOM), the health arm of the National Academy of Sciences.

Today, the NICHD debuted its Hunter Kelly Newborn Screening Research Program in honor of Hunter and his family’s work.