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Adolescence is a critical period of development that can have lasting effects on physical and emotional health.

The ATN is a research network devoted to the wellbeing of youth 12 to 24 years old who are HIV-infected or are at risk of infection. The network comprises 14 clinical sites that conduct research and provide adolescents with treatment and support. It is funded by the NICHD, as well as the National Institute on Drug Abuse and the National Institute of Mental Health, two other NIH components.

The antiretroviral drugs used to keep HIV at bay are an unqualified success at preventing the spread of the virus from mother to child. The drugs are not only essential for maintaining the health of a pregnant woman with HIV, they have also nearly eliminated the transmission of HIV to her baby. Among U.S. women, the likelihood of a mother passing the virus on to her child is now less than 1%.

The Maternal and Pediatric Infectious Disease Branch (MPIDB) was formed in 1988 as the Pediatric, Adolescent, and Maternal AIDS Branch. At that time, its mission was to support and conduct domestic and international research on the HIV/AIDS epidemic with a special focus on infants, children, adolescents, and women.

For HIV-infected women in good immune health, taking a three-drug regimen during pregnancy prevents mother-to-child HIV transmission more effectively than taking one drug during pregnancy, another during labor and two more after giving birth, an international clinical trial has found.

Global health research is an important part of the work of the NICHD. In addition to funding research projects directly, the Institute helps other countries build the research capacity that’s so critical to improving health and saving lives.

The child known as the “Mississippi baby”—an infant seemingly cured of HIV that was reported as a case study of a prolonged remission of HIV infection in The New England Journal of Medicine last fall—now has detectable levels of HIV after more than two years of not taking antiretroviral therapy without evidence of virus, according to the pediatric HIV specialist and researchers involved in the case.

Nearly half of adolescents who have had HIV since birth may be at increased risk for cardiovascular disease — including heart attack and stroke — later in life, according to a National Institutes of Health network study.

This February marks the 20th anniversary of the results of Pediatric AIDS Clinical Trials Group Protocol 076—the first study to show that drug therapy could reduce the risk of mother-to-child transmission of HIV/AIDS. The NICHD and the National Institute of Allergy and Infectious Diseases (NIAID) co-funded this study.

More than 30 percent of young males who had sex with other males and who were subsequently enrolled in a government treatment and research network were found to have high levels of HIV, reported researchers from the National Institutes of Health and other institutions.

This year's World AIDS Day activities focus on efforts to eliminate new HIV/AIDS infections in adolescents and young adults, to treat those who are infected, and to make future generations AIDS free. This focus is part of the "Getting to Zero" theme (Zero New HIV Infections, Zero Discrimination, and Zero AIDS Deaths) that currently guides global efforts.

At the annual meeting of the Society for Neuroscience , held in San Diego, California, from November 9–13, more than 30,000 neuroscientists from around the world will share their latest research results and learn about new advances and opportunities in the field.

More than 65 percent of HIV-infected youth had mild to moderate impairments in fine-motor skills, memory, and other cognitive skills, although not enough to affect day-to-day functioning for most, according to a National Institutes of Health network study.

For children who have been HIV-infected since birth, current anti-HIV drug regimens may protect against the delays in puberty that had been seen in HIV-infected children taking older regimens, according to researchers funded by the National Institutes of Health.

Breastfeeding provides many benefits for both mother and baby. The NICHD and other agencies and organizations encourage mothers to breastfeed their babies to capitalize on the many benefits it provides.

Research continues to ensure ART is the best it can be and that those who receive the treatment remain healthy. The NICHD and other NIH Institutes continue to make this research a priority through the Pediatric HIV/AIDS Cohort Study (PHACS).

The combinations of anti-HIV drugs recommended for pregnant women do not appear in general to increase their children’s risk for language delay, according to a study from a National Institutes of Health research network.

With 11 research programs, more than 75 researchers, and more than 1,100 support staff, the NICHD's DIR is among the largest at the NIH. But with good reason—The NICHD's DIR also has one of the broadest research portfolios at the NIH, covering nearly all aspects of human development and reproduction.

For children who have had HIV-1 infection since birth, the combination drug therapies now used to treat HIV appear to protect against the heart damage seen before combination therapies were available, according to researchers in a National Institutes of Health network study.

Millions of people around the world are affected by STDs and sexually transmitted infections (STIs). Although some of these infections have few or minor symptoms, others can cause infertility and cancer, or—in the case of untreated HIV infection—death.