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Conversation between Rebecca Lazeration and three NICHD researchers who are working to advance the field of reproduction science.

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With 11 research programs, more than 75 researchers, and more than 1,100 support staff, the NICHD's DIR is among the largest at the NIH. But with good reason—The NICHD's DIR also has one of the broadest research portfolios at the NIH, covering nearly all aspects of human development and reproduction.

On December 5, 2012, the NICHD released the Scientific Vision: The Next Decade, the culmination of a collaborative process that began in 2011 to identify the most promising scientific opportunities for the Institute and the research community to pursue over the next decade. The Vision statement was made available during the NICHD’s 50th anniversary colloquium.

​Alan Guttmacher, M.D., Director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) announced a number of changes to streamline the institute’s organizational structure and accelerate the exchange of scientific ideas.

A document charting a research course for the many collaborators who share an interest in promoting the science concerning human development through the life span, child health, women's health, and rehabilitation research is now available online.

As the Institute marks its golden anniversary, we look back on the NICHD's early years, its scientific accomplishments, and its future.

According to the Centers for Disease Control and Prevention (CDC), infertility affects about 12% of all people of reproductive age—women and men—in the United States attempting to get pregnant. Other estimates suggest that the numbers are even higher

During their lifetimes, many women will face a wide array of health issues. Some will seek treatment for gynecological conditions, such as endometriosis and uterine cancer. Others will experience conditions that affect both males and females, but that follow a different course in women, such as heart disease. Women's health is also affected by factors like socioeconomic status and race/ethnicity, sometimes in ways that they cannot control directly.

In a study of mice, researchers have slowed an immune system attack on the ovaries. The mice developed a disorder resembling primary ovarian insufficiency (POI), a menopause-like condition that affects women under the age of 40, sometimes years or even decades before normal menopause. The study was conducted by scientists at the National Institutes of Health and the University of California, San Francisco (UCSF).

The 2010 DIR Annual Report illustrates the impressive accomplishments that result when dozens of PIs, more than 350 trainees, and approximately 1,200 staff all work toward the same goal of improving human health.

Young women with the menopause-like condition, primary ovarian insufficiency, are much more likely than other women to experience depression at some point during their lives, according to a study from the National Institutes of Health. The finding suggests that all women diagnosed with the condition should be evaluated for depression.

Researchers supported by the National Institutes of Health have for the first time activated mouse egg cells at the earliest stage of their development and brought them to maturity. In a related experiment, the researchers replicated the finding by also bringing human eggs to maturity in the laboratory.

The Division’s research programs address topics ranging from molecular and cellular biology, genetics, and endocrine and genetic disorders, to physical biology, neurosciences, immunology, reproduction, and behavioral research. Its projects are organized around the theme of the orchestration of life by molecular messengers.

The National Institutes of Health has developed a research plan to advance the understanding of fragile X syndrome and its associated conditions, fragile X-associated tremor/ataxia syndrome and fragile X-associated primary ovarian insufficiency. Fragile X syndrome causes intellectual and developmental disabilities and results from a mutation in a gene on the X chromosome.

A comprehensive plan to help health care professionals diagnose and treat primary ovarian insufficiency--a menopause-like condition affecting girls and young women that may occur years before normal menopause is expected--has been developed by a scientist at the National Institutes of Health.

Researchers funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) are seeking volunteers for a study to treat infertility in women with polycystic ovary syndrome (PCOS).

Women with spontaneous premature ovarian failure (POF) are three hundred times more likely than members of the general population to develop a serious condition in which the body attacks the adrenal glands, according to a study by researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) are recruiting women who have premature ovarian failure--formerly known as premature menopause--to determine if restoring testosterone will help prevent osteoporosis.

An investigational drug that helps insulin to function more efficiently appears to combat infertility in women with polycystic ovary syndrome (PCOS), the most common cause of female infertility, according to a research team funded in part by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).