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Preterm infants born to people who have been vaccinated for COVID-19 had roughly the same levels of antibodies to the spike protein of SARS-CoV-2 as term infants born to vaccinated people, allaying concerns that fewer antibodies might pass to preterm infants.

By late 2022, widespread COVID-19 vaccination of pregnant people likely halted a spike in the preterm birth rate that began at the start of the pandemic, suggests a new study. The findings underscore the need for pregnant people to keep current on COVID-19 vaccination.

The health of pregnant individuals and new mothers in the nation’s prisons should be prioritized to avoid future public health crises from COVID-19, according to an analysis by NICHD-funded investigators. Recommended policy changes include early release, when possible, because pregnant people are at high risk from COVID-19, and prisons are not well-equipped to provide the necessary medical care. Moreover, prisons should promote COVID-19 vaccination and develop targeted messages for this population to counteract vaccine misinformation.

Infants born in 2020 through mid-2021 to women with COVID-19 weighed less at birth, but grew at a faster rate than a comparable group born to women who did not have COVID-19, according to a study funded by the National Institutes of Health. Previous studies have found that preterm infants and other infants who are small or underweight at birth and who undergo catch-up growth in the first year are at higher risk for later life obesity, heart disease, high blood pressure and diabetes, compared to infants born at normal weight. The authors called for additional studies of infants whose mothers had COVID-19 during pregnancy to learn if they have increased health risks later in life.

Read about NICHD’s research findings and activities from 2022.

Compared to giving birth in 2019, giving birth in 2020 during the early stages of the pandemic was not associated with a higher risk of maternal death or a serious complication of pregnancy, suggests a study funded by the National Institutes of Health.

U.S. rates of pregnancy-associated homicide—deaths that occur among women who are pregnant or had been pregnant within one year—rose in 2020 during the COVID-19 pandemic, according to a recent NICHD-funded study.

The Pfizer-BioNTech and Moderna COVID-19 vaccines may offer slightly more protection during pregnancy against SARS-CoV-2, compared to the Jansen/Johnson & Johnson vaccine, suggests a study funded by the National Institutes of Health. Vaccination during the first and third trimesters appears to result in higher antibody-stimulated immune responses than vaccination in the second trimester. It also may lead to greater transfer of antibodies from maternal blood to the placenta.

The COVID-19 pandemic has magnified mental and emotional health challenges for all of us. Dr. Bianchi highlights research to understand and address factors affecting the mental health of children and their parents.

Vaccinating women against SARS-CoV-2 in mid to late pregnancy could provide their infants at least some protection against COVID-19 through six months of age, suggests a small study funded by the National Institutes of Health. Compared to infants born to mothers who had COVID-19 during pregnancy, infants born to vaccinated mothers were much more likely to have antibodies against the virus.

Pregnant women with COVID-19 appear to be at greater risk for common pregnancy complications—in addition to health risks from the virus—than pregnant women without COVID-19, suggests a study funded by the National Institutes of Health.

Infants born during the pandemic—regardless of whether their mothers had COVID-19 during pregnancy—scored slightly lower on certain tests of neurodevelopment at 6 months old, compared to a similar group of infants born before the pandemic, according to a study funded by the National Institutes of Health. The findings suggest that children born during the pandemic may need long-term monitoring to rapidly identify any future lags in development. The researchers theorized that maternal stress resulting from the pandemic could have effects on children’s neurodevelopment.

Small NIH study contributes to understanding of COVID-19 during pregnancy.

Read about NICHD’s research findings and activities from 2021.

Dr. Bianchi discusses NICHD-led research on long COVID in children.

The National Institutes of Health will support a four-year follow-up study on the potential long-term effects of COVID-19 on women infected with SARS-CoV-2 during pregnancy. The study will also follow their offspring for any potential long-term effects.

No serious adverse events were reported by 180 breastfeeding women receiving either the Pfizer or Moderna vaccine, either among themselves or in their infants, according to a study funded by the National Institutes of Health. For the mothers, adverse events included muscle and body aches, fever and vomiting, pain, redness, swelling, or itching at the injection site.

NIH-supported program reduces maternal deaths, complications in rural Guatemalan communities.

A panel of experts convened by NICHD has recommended standardized criteria to define infection of the placenta with SARS-CoV-2, the virus that causes COVID-19. Their recommendations aim to help streamline research on SARS-CoV-2 infection during pregnancy and ultimately optimize clinical care.

Trophoblasts—the outermost fetal cells of the placenta—may be able to contain SARS-CoV-2 and prevent it from spreading to the fetus even though these cells appear to be susceptible to infection by the virus, a study by NIH-funded researchers suggests. Further research into how trophoblasts might contain the virus could lead to ways to prevent COVID-19 in children and adults. The findings may also lead to insights on why fetuses are only rarely infected with SARS-CoV-2.