Traces of genetic material from the placenta and other organs circulating in a pregnant woman’s blood stream could potentially be used to predict the risk for complications in later pregnancy, according to a new NICHD-supported study.
News
NICHD issues News Releases and Media Advisories to the news media. Spotlight and Research Feature articles explain NICHD research findings and public health issues to the general public. An Item of Interest is a short announcement of relevant information, such as a notable staff change.
Science Update: DNA sequencing technique helpful for identifying genetic causes of fetal fluid buildup, NIH-funded study suggests
Researchers funded by the National Institutes of Health have used a rapid DNA sequencing technique to identify gene variants in roughly a third of cases of nonimmune Hydrops fetalis (NIHF), a serious condition in which a fetus develops fluid buildup inside the abdominal cavity, lungs, or other parts of the body. The findings suggest that the DNA sequencing technique, known as exome sequencing, could be used to provide information unavailable with current genetic testing methods.
Item of Interest: NICHD Awards Grants for Firearm Injury and Mortality Prevention Research
NICHD has awarded nearly $2.5 million in grants to support research aimed at improving the understanding and prevention of firearm violence and mortality.
Media Advisory: NIH-funded study suggests link between pediatric hospitalization and rising unemployment
Pediatric hospitalization rates increase when unemployment levels rise, suggests a National Institutes of Health-funded analysis of data from 14 states spanning 12 years. The study authors concluded that more research is needed to understand how to potentially offset the declining health conditions brought on during economic downturns.
Director's Corner: It’s a Family Matter: The NIH INCLUDE Project
The pandemic reinforces why the NIH INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project matters to families and communities.
Item of Interest: NIH Selects Centers to Advance Research on Fragile X Syndrome and Related Conditions
NIH announces funding for three centers for collaborative research on Fragile X syndrome, the most common inherited form of intellectual and developmental disability, and related conditions.
Director's Corner: Push to IMPROVE health outcomes for pregnant women
NIH has launched a new initiative that will combat the growing problem of maternal mortality and morbidity in the United States.
Media Advisory: Negative pressure wound therapy does not cut infection risk in obese women after cesarean delivery
Negative pressure wound therapy (NPWT) does not appear to lower the risk of infection for obese women after cesarean delivery, suggests a study funded by the National Institutes of Health. The treatment involves placing a low-pressure pump over a closed surgical wound to create negative air pressure. Earlier studies had suggested that NPWT might reduce infection risk and promote healing after surgery. The study of more than 1,600 obese women found no significant difference in infection between women treated with NPWT and those receiving standard wound dressing.
Science Update: NIH-funded study identifies genetic causes of stillbirth
Researchers funded by the National Institutes of Health have found that of 246 stillbirths, about 6% likely resulted in mutations to single genes. Of these, 9 cases resulted from gene variants implicated in stillbirth and 6 resulted from variants that had been suspected in stillbirths. The researchers concluded that the genome mapping method, called whole exome sequencing, could potentially provide information for counseling families of stillborn infants and to inform medical care of future pregnancies.
Media Advisory: NIH-supported study to track prevalence and impact of SARS-CoV-2 among pregnant women in low- and middle-income countries
The study of approximately 16,000 pregnant women will continue 12 months after childbirth and compare maternal, fetal and newborn outcomes of participants infected with the virus to those of pregnant women who have not.
Media Advisory: People with intellectual and developmental disabilities disproportionately affected by COVID-19
The COVID-19 pandemic has taken a disproportionate toll on people with intellectual and developmental disabilities (IDDs), write the directors of the Intellectual and Developmental Disabilities Research Centers (IDDRC) Network, a nationwide group funded by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development. A large number of people with IDD who require in-person care have lost the support of trained caregivers and community service providers due to the pandemic.
Item of Interest: Theresa Cruz appointed director of NICHD’s National Center for Medical Rehabilitation Research
Theresa Hayes Cruz, Ph.D., has been selected as director of the National Center for Medical Rehabilitation Research (NCMRR).
Release: NIH-funded project seeks to identify children at risk for MIS-C
The National Institutes of Health has announced research funding to encourage the development of approaches that identify children at high risk for developing Multisystem Inflammatory Syndrome in Children (MIS-C), thought to be a severe complication of COVID-19. Up to $20 million will be awarded to successful research proposals over four years.
Media Advisory: New tool compares rates of severe pregnancy complications across U.S. hospitals
Scoring system developed by NIH-funded researchers standardizes patient data to aid research, surveillance and improvement initiatives.
Spotlight: Boosting women’s health by supporting menstruation research
NICHD has supported gynecologic and reproductive health research for decades. Learn more about its leading role in menstruation research.
Media Advisory: Placenta lacks major molecules used by SARS-CoV-2 virus to cause infection
The placental membranes that contain the fetus and amniotic fluid lack the messenger RNA (mRNA) molecule required to manufacture the ACE2 receptor, the main cell surface receptor used by the SARS-CoV-2 virus to cause infection, according to a study by researchers at the National Institutes of Health.
Science Update: Drug-containing nanoparticles reduce size of fibroid tumors in mice
In a study of mice, NIH-funded researchers have developed a prototype technique for shrinking uterine fibroids—sometimes painful, noncancerous tumors that form in the uterus. The method involves encasing a tumor-killing drug in nano-sized spheres called liposomes and delivering them directly to the fibroids through the bloodstream. The findings set the stage for studies to determine if the method is safe and effective for treating fibroids in people.
Science Update: Screen time before bed linked to less sleep in children with impulse control problems, according to NIH-funded study
Screen time before bed may affect kids differently, depending on whether they have a particular personality trait, suggests a study funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Nighttime electronic media use was linked to less sleep in children who scored lower on a measure of effortful control—the ability to override inappropriate impulses, focus attention, and complete difficult tasks. In contrast, bedtime screen use was not associated with sleep reduction in children who scored high in effortful control.
Media Advisory: Genetic analysis suggests distinct subtypes of polycystic ovary syndrome
Polycystic ovary syndrome, an infertility disorder affecting at least 15% of reproductive-age women, may have at least two different subtypes, suggests a study funded by the National Institutes of Health. The findings could provide important information on the possible causes of PCOS and for developing more effective ways to treat the condition.
Science Update: Mouse study links embryo culture after IVF with reduced placental, fetal growth
A mouse study funded by the National Institutes of Health suggests that a step in the in vitro fertilization (IVF) procedure could account for the higher rate of complications in pregnancies resulting from this form of assisted reproductive technology (ART). The researchers linked the culture of embryos in laboratory dishes after fertilization with impaired growth of the placenta, smaller fetal size, and a higher risk of preeclampsia, a serious pregnancy-related blood pressure disorder.