Text Alternative of Video: Launching the Zika in Infants and Pregnancy (ZIP) Study

To view the original video, please go to http://www.nichd.nih.gov/news/releases/Pages/zika_zip_06202016.aspx

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NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development logo
Research for a Lifetime
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In June 2016, NIH launched the Zika in Infants and Pregnancy (ZIP) study, a multi-country study to evaluate the health risks that Zika virus infection poses to pregnant women and their developing fetuses and infants.

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Video clip of mosquitoes flying against a white background.
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The study aims to enroll as many as 10,000 pregnant women at sites in Latin America and the Caribbean.

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Photograph of a pregnant woman who is outdoors and applying insect repellent.
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Camera view of Dr. Catherine Y. Spong

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Catherine Y. Spong, M.D.
Acting Director, NICHD, NIH
Dr. Catherine Y. Spong: We need to be able to tell a woman and tell a family, what is the risk of having Zika virus on pregnancy…
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A pregnant woman is reclined in a hospital bed and talking to her doctor (female). The doctor is filling out a chart.
Dr. Spong: … and we need to be able to tell her that given the constellation of pregnancy itself, so…
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A different pregnant woman is sitting in an exam room, and her blood pressure is being taken by a nurse (female).
Dr. Spong: … if she is in her first trimester, if she is under 13 weeks, how is that different…
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Another pregnant woman is sitting in a waiting room with her husband. Both are rubbing her belly.
Dr. Spong: … than if she is 20 weeks or if she is at 25 weeks?
Camera view of Dr. Spong. Dr. Spong: Does it matter if she has had some other co-infection? Does it matter if she was symptomatic with the virus, meaning she had the rash or the fever, or if she was asymptomatic with the virus? Does that change the impact for the pregnancy itself? Does it matter how the virus was obtained, whether it was sexually transmitted or…
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Photograph of an Aedes mosquito on skin.
Dr. Spong: … from a mosquito? And then, what are the roles…
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Blurry view of people walking on a crowed sidewalk, next to vehicles moving along the street.
Dr. Spong: … of these other environmental factors? So is the environment…
Camera view of Dr. Spong. Dr. Spong: … that she’s living in going to make the infection with Zika worse for her pregnancy itself?
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Researchers plan to document the frequency of miscarriage, preterm birth, microcephaly, and other complications among women who were infected with Zika virus and those who were not.

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Video of an ultrasound exam, zoomed on the technician’s hand moving the probe across a pregnant woman’s belly. Video switches to an ultrasound screen showing a moving fetus.
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Camera view of Dr. Nahida Chakhtoura (left) and Dr. Rohan Hazra (right)

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Nahida Chakhtoura, M.D.
Medical Officer, NICHD
Dr. Nahida Chakhtoura: What it will do is actually inform the full spectrum of what…
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Zoomed view of the kicking feet of a newborn in the hospital. There is an ID tag on the baby’s foot.
Dr. Chakhtoura: … we may be able to see with Zika infection…
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Illustration of a baby with microcephaly (left) and a baby with a typical head size (right). In the microcephaly image, a dashed line represents the boundary of a typical head size. The illustration also has the CDC logo in the corner.

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Baby with Microcephaly

Baby with Typical Head Size
Dr. Chakhtoura: … outside of just microcephaly, so there may be subtle…
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A baby is lying down, and a doctor is examining the baby’s chest with a stethoscope.
Dr. Chakhtoura: … abnormalities that will affect short-term…
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A mom is holding her baby in her lap at the doctor’s office. The doctor (female) is holding a chart and discussing the contents with mom.
Dr. Chakhtoura: … and long-term outcomes for the infants and…
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A baby’s hand is seen grasping an adult’s finger, as the baby sucks his or her thumb in the background.
Dr. Chakhtoura: … and children, so it will be important to know what those are so that…
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A mom, reclined on a hospital bed, is holding her newborn infant, quickly touches her baby’s nose, and then holds her baby’s hand.
Dr. Chakhtoura: … we can have a better structure of what we can do and help…
Camera view of Dr. Chakhtoura and Dr. Hazra. Dr. Chakhtoura: … treat children that are affected by Zika.
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Photograph of Zika virus particles.

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Zika virus particles (blue)
Credit: CDC

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The study also will evaluate how the timing of Zika infection affects pregnancy outcomes and what role environmental and other factors may play in the health of study participants and their newborns.
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Camera view of Dr. Chakhtoura and Dr. Hazra.

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Rohan Hazra, M.D.
Branch Chief, NICHD
Dr. Rohan Hazra: Some of those factors could be
pre-existing infection with a similar virus, dengue virus, which we know is endemic in Brazil. Others have talked about potentially other exposures…
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Photograph of a crop spraying tractor in a field.
Dr. Hazra: … such as pesticides or insecticides.
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Photograph of a researcher holding a syringe next to a fluorescent tube.
Dr. Hazra: There may be genetic factors or nutritional factors…
Camera view of Dr. Chakhtoura and Dr. Hazra. Dr. Hazra: … so we're going to have, by systematically studying this cohort, we'll be able to I think address a lot of these important questions.
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(Edit/effect) NIH/Eunice Kennedy Shriver National Institute of Child Health and Human Development logo appears against a black screen.
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