NIH-funded study also observes less neurological impairment among surviving infants
Very early preterm infants are more likely to survive than in previous years, and the survivors are less likely to have neurological problems, according to an analysis of records from a National Institutes of Health research network.
Researchers found that of the more than 4,000 infants born at 11 sites within the network from 2000 to 2011, survival rates increased from 30 percent to 36 percent. The proportion of survivors who did not have a neurological or developmental impairment increased from 16 percent to 20 percent. The authors theorize that these improvements are a result of advances in the care provided to expectant mothers and their newborns.
The study appears in the New England Journal of Medicine.
“Our study provides important information for physicians and family members planning the care of these extremely fragile newborns,” said study author Rosemary Higgins, M.D., a program scientist at NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). The study was conducted by researchers in the NICHD-funded Neonatal Research Network.
Infants in the study were born between the 22nd and 24th week of pregnancy, far earlier than the 40 weeks generally expected for a pregnancy to reach term. Those born from 2008 to 2011 had the lowest death rate (64 percent). From 2004 to 2007, the death rate was 70 percent, unchanged from 2000 to 2003.
Dr. Higgins stressed that the results encompass trends for a large number of infants at multiple research sites, but they should not be used to predict the outcome for an individual child.
“Every individual is different, and no single source of information can precisely predict a baby’s chances of survival or disability,” she said. “But our study’s findings do provide important information that physicians and family members can consult to help determine treatment strategies.”
Providing care to infants born so early is often challenging. Physicians and family members can be reluctant to expose an infant to sometimes painful life-support procedures. Those offered active treatment may survive, but may have hearing loss, blindness, cerebral palsy, and severe intellectual disability.
The study authors wrote that, in the past, many experts had feared that advances leading to improvements in survival among extremely preterm infants might also result in a higher proportion of infants with disabilities. However, in the current study, researchers found that across all three time intervals, the percentage of infants who survived with a disability did not change significantly.
The authors wrote that the increases in overall survival and survival without neurological harm likely result from improvements in the care given to mothers and newborns. One potential contributing factor is the wider use of antenatal steroids. These drugs, which are given to women at risk for preterm birth, help the infant’s lungs mature, leaving the infant less reliant on ventilation therapy, which can sometimes damage the lungs and lead to infections.
REFERENCE: Younge N, et al. Survival and Neurodevelopmental Outcomes among Periviable Infants. N Engl J Med 2017;376:617-28. DOI: 10.1056/NEJMoa1605566.
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About the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD): NICHD conducts and supports research in the United States and throughout the world on fetal, infant and child development; maternal, child and family health; reproductive biology and population issues; and medical rehabilitation. For more information, visit NICHD’s website.
About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.
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