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NICHD Neonatal Research Network (NRN): Extremely Preterm Birth Outcome Data

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What do the data show?

Using the five factors, researchers determined infant outcomes for the sample.  These outcomes include data on survival and the following neurodevelopment outcomes:

(For more information, please consult the article: Tyson JE, Parikh NA, Langer J, Green C, Higgins RD. [2008]. Intensive care for extreme prematurity: Moving beyond gestational age. N Engl J Med, 358, 1672-1681.)

The tables below list average outcomes for the NRN sample that can be used for general reference and may help to indicate how current outcomes in individual hospitals may differ from those in the Network during the study. The first table provides outcomes data for all the infants in the sample; the second table provides outcomes data only for infants in the sample who were mechanically ventilated, which means that the doctors attempted to assist the infant’s breathing with the help of a breathing device or machine.

Outcomes for All Infants in the Sample

Gestational Age
(In Completed Weeks)
Death Before
NICU Discharge
Outcomes at 18 to 22 Months Corrected Age*
Death Death/ Profound
Neurodevelopmental
Impairment
Death/Moderate to Severe Neuro-
developmental Impairment
22 Weeks 95% 95% 98% 99%
23 Weeks 74% 74% 84% 91%
24 Weeks 44% 44% 57% 72%
25 Weeks 24% 25% 38% 54%

* Determination of Death/Profound Neurodevelopmental Impairment and Death/Moderate to Severe Neurodevelopmental Impairment based on 4,165 infants whose outcomes were known at 18 to 22 months corrected age; determination of Death based on a denominator of all 4,446 cohort infants.

Outcomes Only for Mechanically Ventilated Infants in the Sample

Gestational Age
(In Completed Weeks)
Death Before
NICU Discharge
Outcomes at 18 to 22 Months Corrected Age**
Death Death/ Profound
Neurodevelopmental
Impairment
Death/Moderate to Severe Neuro-
developmental Impairment
22 Weeks 79% 80% 90% 95%
23 Weeks 63% 63% 76% 87%
24 Weeks 40% 41% 55% 70%
25 Weeks 23% 24% 37% 54%

**For mechanically ventilated infants, determination of Death/Profound Neurodevelopmental Impairment and Death/Moderate to Severe Neurodevelopmental Impairment based on 3,421 infants whose outcomes were known at 18 to 22 months corrected age; determination of Death based on a denominator of all 3,702 cohort infants.

Please note that these data provide only possible outcomes, and that the estimates apply only at birth.  It is also important to note that outcomes change over time and that they differ in different centers and for a variety or reasons, including NICU features, patient population, obstetric complications and care, and care after discharge home. Outcomes in different centers differed more for death only than for other outcomes. For instance, the ratio of the observed rate of outcomes among mechanically ventilated infants in different centers relative to that expected from the outcomes for the Network as a whole varied more for Death (0.60-1.38), than for Death/Profound Neurodevelopmental Impairment (0.75-1.23) or Death/Moderate to Severe Neurodevelopmental Impairment (0.85-1.17).

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Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012
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