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Medicinal Chemistry Facility (MCF)

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Overview

The MCF is one of four contracts used by the Contraceptive Discovery and Development Branch (CDDB), formerly the Contraception and Reproductive Health (CRH) Branch, to support research on the discovery, optimization, and development of male and female contraceptive agents.

This facility provides NICHD-supported researchers and other investigators with technology, infrastructure, and know-how for drug discovery and optimization. The MCF will utilize high-throughput screening (HTS) assays of compound libraries for hits to lead discoveries that inhibit validated male and female contraceptive targets. A targeted library may be synthesized for further testing for cases where a lead has been identified. The MCF will carry out a further optimization step that encompasses modeling and structure biology with iterative synthesis and biological testing for achieving highly specific and potent drug candidates. The lead optimization steps will revolve around structure- based drug design (SBDD) where modeling, structure biology, synthesis, and biological assays will play critical roles in the iterative process of determining optimal structure and activity.
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Topic Areas

The MCF is engaged in early discovery for optimization of small molecules directed at validated male and female contraceptive targets.

More Information

Last Updated Date: 01/24/2014
Last Reviewed Date: 01/24/2014
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology