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Pelvic Pain: Clinical Trials

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The NICHD conducts and supports a variety of clinical research projects related to pelvic pain. Select a link below to learn more about these projects.

Featured NICHD Clinical Trials on Pelvic Pain

  • Botulinum Toxin for Pelvic Pain in Women with Endometriosis
    Some women with endometriosis have chronic pelvic pain that may be caused by spasms of the pelvic floor muscles, which can be identified by examination. Preliminary studies suggest that botulinum toxin may be able to treat these muscle spasms and reduce the associated pain. This study is testing to see if botulinum toxin injections into the pelvic floor muscles can decrease pain and spasms in women with pelvic pain.
  • The FIRSTT Study: Comparing MRgFUS (MR-guided Focused Ultrasound) and UAE (Uterine Artery Embolization) for Uterine Fibroids
    This study is comparing the safety and effectiveness of two standard fibroid treatments: magnetic resonance imaging (MRI)-guided focused ultrasound surgery (MRgFUS) and uterine artery embolization (UAE). The study also will collect information to understand which symptoms bother women with fibroids the most.
  • Global Study of Women's Health
    The purpose of this study is to collect information about the impact of endometriosis among women worldwide, in terms of prevalence, diagnostic delay, quality of life, economic effect indicators, health care utilization, and risk factors. The study will help assess whether or how endometriosis-related pelvic pain differs from other kinds of pelvic pain.
  • Pelvic Pain in Women with Endometriosis
    This study is examining pelvic pain associated with endometriosis and examining better approaches to treatment. Standard treatments—altering hormone levels to prevent endometrial tissue growth or surgically removing endometrial tissue—treat pelvic pain only temporarily. This study is investigating the role of sex hormones, immune chemicals, stress hormones, and genes in pelvic pain, with the additional intent to determine how the nerve, muscle, and skeletal systems are involved in this pain.
  • A Trial of Gabapentin in Vulvodynia: Biological Correlates of Response
    This trial will test whether gabapentin can effectively reduce vulvar pain. More than 100 women are expected to enroll.

NICHD Clinical Trials

ClinicalTrials.gov Search Results

Information on current NIH-sponsored clinical trials on pelvic pain is available at the link below or by calling 1-800-411-1222.

Last Updated Date: 11/30/2012
Last Reviewed Date: 04/12/2013
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology