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Hoffman, Dax A

Formal Title:

Senior Investigator

Phone:

301-402-6772

Email:

dh347r@nih.gov

Address:

35 CONVENT DR Room 3C905, MSC 3715
Bethesda Md 20892-3715
For FedEx use:
Bethesda Md 20892

Biosketch:

Dr. Hoffman received his B.S. in Genetics from the University of Minnesota in 1994 and his Ph.D. from Baylor College of Medicine 1999, where he studied dendritic K+ channels with Dr. Dan Johnston. During a postdoctoral fellowship with Bert Sakmann at the Max Planck Institute for Medical Research in Heidelberg Germany, he investigated synaptic plasticity and Ca2+ signaling in transgenic and gene-targeted mice. Dr. Hoffman became head of the Molecular Neurophysiology and Biophysics Unit, NICHD in 2002. His laboratory explores dendritic signal processing in CA1 pyramidal neurons of the hippocampus.

Publications (PubMed):

Loss of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling during Elevated Activity Causes Vulnerability in Hippocampal Neurons.
Dynamic Regulation of Synaptic Maturation State by Voltage-Gated A-Type K+ Channels in CA1 Hippocampal Pyramidal Neurons.
Effects of genetic deletion of the Kv4.2 voltage-gated potassium channel on murine anxiety-, fear- and stress-related behaviors.
A novel point mutation in the KCNJ5 gene causing primary hyperaldosteronism and early-onset autosomal dominant hypertension.
Aberrant dendritic excitability: a common pathophysiology in CNS disorders affecting memory?
KCNJ5 mutations in the National Institutes of Health cohort of patients with primary hyperaldosteronism: an infrequent genetic cause of Conn's syndrome.
DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.
A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density.
Differential cycling rates of Kv4.2 channels in proximal and distal dendrites of hippocampal CA1 pyramidal neurons.
AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.
Kv4.2 block of long-term potentiation is partially dependent on synaptic NMDA receptor remodeling.
Dendritic ion channel trafficking and plasticity.
KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.
Biphasic somatic A-type K channel downregulation mediates intrinsic plasticity in hippocampal CA1 pyramidal neurons.
Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons.
Firing first: compensatory changes in K+ channel knockout mice preserve excitability but not synaptic scaling.
Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons.
Protein kinase a mediates activity-dependent Kv4.2 channel trafficking.
Neuregulins and neuronal plasticity: possible relevance in schizophrenia.
Potassium channels: newly found players in synaptic plasticity.
Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons.
Neuregulin-1 reverses long-term potentiation at CA1 hippocampal synapses.
Kv4 potassium channel subunits control action potential repolarization and frequency-dependent broadening in rat hippocampal CA1 pyramidal neurones.
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology