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Sargent, Tom

Formal Title:

Senior Investigator

Responsibilities:

Head of the Section on Vertebrate Development.

Phone:

301-496-0369

Email:

sargentt@mail.nih.gov

Address:

6 Center Dr Room 4B412, MSC 2790
Bethesda Md 20892-2790
For FedEx use:
Bethesda Md 20892

Topics in my portfolio:

Biosketch:

Tom Sargent received his Bachelor of Arts degree in 1975 from Indiana University and his Ph.D. in Biochemistry from Caltech in 1981. He was a postdoc in Igor Dawid's lab at NIH, and has been a tenured scientist in the National Institute of Child Health and Human Development (NICHD) since 1989. Dr. Sargent's research interests have been in vertebrate developmental biology, and he has made many contributions, including production of one of the first mammalian genomic libraries (Sargent et al., 1979), and one of the first subtracted cDNA libraries (Sargent and Dawid, 1983). Dr. Sargent and colleagues were the first to demonstrate the requirement for cell-cell communication in mesoderm formation in the frog embryo (Sargent et al., 1986), and that dissociation of frog embryonic cells could trigger neural development (Sato and Sargent, 1989). The Sargent lab discovered the role of the transcription factor AP-2 in regulating epidermal gene expression (Snape et al., 1991), the function of Eph class receptors in regulating cell adhesion (Winning et al., 1996), and the roles of the Dlx3 gene in epidermal (Morasso et al., 1996) and placental (Morasso et al., 1999) development in the mouse. His lab also showed that TFAP2 is required for induction of neural crest in Xenopus, and used this to identify downstream target genes that are important in neural crest development.  In addition to his work at NIH, Dr. Sargent has been an Associate Clinical Professor in the Institute for Biomedical Sciences at The George Washington University, in Washington, D.C. where he has taught courses in molecular biology and medical genetics.

Publications (PubMed):

 
Title Authors Publication Date
Maternal pak4 expression is required for primitive myelopoiesis in zebrafish.Law SH,Sargent TDMech Dev2012 Sep 29
Generation and characterization of a novel neural crest marker allele, Inka1-LacZ, reveals a role for Inka1 in mouse neural tube closure.Reid BS,Sargent TD,Williams TDev Dyn2010 Apr
Inca: a novel p21-activated kinase-associated protein required for cranial neural crest development.Luo T,Xu Y,Hoffman TL,Zhang T,Schilling T,Sargent TDDevelopment2007 Apr
Myosin-X is required for cranial neural crest cell migration in Xenopus laevis.Hwang YS,Luo T,Xu Y,Sargent TDDev Dyn2009 Oct
Transcriptional regulation at the neural plate border.Sargent TDAdv Exp Med Biol2006
PCNS: a novel protocadherin required for cranial neural crest migration and somite morphogenesis in Xenopus.Rangarajan J,Luo T,Sargent TDDev Biol2006 Jul 1
Msx1 and Msx2 have shared essential functions in neural crest but may be dispensable in epidermis and axis formation in Xenopus.Khadka D,Luo T,Sargent TDInt J Dev Biol2006
Expression of TFAP2beta and TFAP2gamma genes in Xenopus laevis.Zhang Y,Luo T,Sargent TDGene Expr Patterns2006 Aug
Developmental expression of Xenopus fragile X mental retardation-1 gene.Lim JH,Luo T,Sargent TD,Fallon JRInt J Dev Biol2005
Regulatory targets for transcription factor AP2 in Xenopus embryos.Luo T,Zhang Y,Khadka D,Rangarajan J,Cho KW,Sargent TDDev Growth Differ2005 Aug
AP-2alpha selectively regulates fragile X mental retardation-1 gene transcription during embryonic development.Lim JH,Booker AB,Luo T,Williams T,Furuta Y,Lagutin O,Oliver G,Sargent TD,Fallon JRHum Mol Genet2005 Jul 15
Induction of neural crest in Xenopus by transcription factor AP2alpha.Luo T,Lee YH,Saint-Jeannet JP,Sargent TDProc Natl Acad Sci U S A2003 Jan 21
Transcription factor AP-2 is an essential and direct regulator of epidermal development in Xenopus.Luo T,Matsuo-Takasaki M,Thomas ML,Weeks DL,Sargent TDDev Biol2002 May 1
Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology