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Pacak Lab: Section on Medical Neuroendocrinology

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Overview

The Section on Medical Neuroendocrinology, under the direction of Karel Pacak, continues to focus on neuroendocrine disorders, particularly pheochromocytoma. The Section used micro-computed tomography for early diagnosis of ectopic pheochromocytoma tumor in the liver of the nude mouse, a technique that may be applied to the human and that would be an excellent way to diagnose early small metastases. In addition, members of the Section noted that mutations of the SDHB gene are associated with one-half of all malignancies originating from extra-adrenal paragangliomas. The high frequency of SDHB germline mutations among patients with malignant disease, particularly when originating from adrenal paraganglioma, may justify giving high priority to SDHB germline mutation testing in such patients.

Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Karel Pacak
Senior Investigator
Program in Reproductive and Adult Endocrinology
Phone: 301-496-5800
Fax: 301-402-0884
E-mail: karel@mail.nih.gov

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology