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Sargent Lab: Section on Vertebrate Development

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Overview

Tom Sargent, who heads the Section on Vertebrate Development, and colleagues study TFAP2–regulated genes in the cranial neural crest (CNC). In previous years, the group investigated MyosinX, which encodes a non-muscle motor protein, and Inka, a novel protein that promotes actin stress-fiber formation and inhibits microtubule acetylation, probably through interactions with pak4 (p21-activated kinase 4), a Rho-GTPase effector molecule. More recently, the focus has shifted to the functions of pak4 itself in zebrafish development, where it behaves as a maternal effect gene and is required for somite morphogenesis, molecular signaling of early blood cell development, and other functions. The group is also developing imaging strategies for monitoring cell-cell signaling in living zebrafish and is using a mutant version of the homeobox gene dlx3, corresponding to a human genetic disorder, to probe neural crest development, again in zebrafish. ​​​​​​​​​​​​​​ ​​​​​​​​​​
Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Tom Sargent
Senior Investigator
Section on Vertebrate Development
Phone: 301-496-0369
Fax: 301-496-0243
Email: sargentt@mail.nih.gov.

Staff Directory
Vision National Institutes of Health Home BOND National Institues of Health Home Home Storz Lab: Section on Environmental Gene Regulation Home Machner Lab: Unit on Microbial Pathogenesis Home Division of Intramural Population Health Research Home Bonifacino Lab: Section on Intracellular Protein Trafficking Home Lilly Lab: Section on Gamete Development Home Lippincott-Schwartz Lab: Section on Organelle Biology