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Maraia Lab: Section on Molecular and Cell Biology

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Overview

Richard Maraia, who heads the Section of Molecular and Cell Biology, studies RNA metabolism, with continued interest in tRNA biogenesis. Efforts focus on RNA 3′-end formation by RNA polymerase III and the RNA 3′-end–stabilizing protein La. The Section's recent data suggest that La-related protein-4 (LARP4) binds to 3′ poly(A) and stabilizes mRNAs. Another focus is on Tit1p, an anticodon loop–modification enzyme that modifies a small subset of tRNAs, and its effects on the subset of mRNAs with cognate codon bias. The Section uses genetics coupled with genome-wide profiling and this-generation sequencing, cell and structural biology, and biochemistry in model systems that include yeast, mammalian cultured cells, and gene-altered mice.

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Last Updated Date: 11/30/2012
Last Reviewed Date: 11/30/2012

Contact Information

Name: Dr Richard J Maraia
Senior Investigator
Section on Molecular and Cell Biology
Phone: 301-402-3567
Fax: 301-480-9354
Email: maraiar@mail.nih.gov.

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