The NICHD conducts and supports a variety of clinical research related to TBI. Select a
link below to learn more about these projects.
Featured NICHD Clinical Trials on TBI
An Acute Neurobehavioral Program for Improving Functional Status After TBI
The purpose of this study is to assess the effectiveness of a 10-session acute-care intervention designed to improve the functional status of patients with TBI. Therapeutic components of the program include cognitive remediation, demonstration, guided self-reflection, rehearsal, and supported practice of skills and strategies.
Life Improvement Following Traumatic Brain Injury (LIFT)
The purpose of this pilot study is to test the effectiveness of a telephone-based and in-person Cognitive Behavioral Therapy (CBT) intervention for treating Major Depressive Disorder following TBI. Participants are randomly assigned to receive one of the following: 1) telephone-based CBT, 2) in-person CBT, or 3) usual care (control).
Study of Citicoline for the Treatment of Traumatic Brain Injury (COBRIT)
Citicoline is a naturally occurring compound that may assist with neuroprotection, neurorecovery, and neurofacilitation after TBI. The primary goal of this multisite study is to assess the efficacy of citicoline compared to placebo on functional and cognitive outcomes in participants with TBI.
NICHD Clinical Trials
ClinicalTrials.gov Search Results
Information on current NIH-sponsored clinical trials on TBI is available at the link below
or by calling 800-411-1222.