Sleep is a complex phenomenon that is essential to normal behavioral and biological functioning. Sleep disturbance in infants and children is of great concern to their parents, but in more general terms, patterns of sleep and circadian rhythms are often overlooked as influences on trajectories of human development. Trends over time in the United States and other developed countries show significant competition between sleep duration and timing and increasing demands and high reward activities. As with other behaviors (e.g., eating, exercise), individuals make daily decisions regarding when and how much to sleep in the context of other social activities, environmental demands, and psychophysiological drives. Such disruptions in sleep patterns subsequently influence basic sleep-wake regulation and circadian regulation, and other time- and state-linked biological processes.
Chronic and acute sleep loss and sleeping outside of the optimal circadian phase can result in persistent alterations in behavior and mechanisms regulating behavior. Investigators have established connections between disrupted circadian regulation, disordered sleep, and decreased ability to form new memories, as well as changes in metabolic regulation, inflammation, and immune response. Furthermore, mutations in genes involved in regulation of circadian rhythms have been shown to have effects on behavioral outcomes including cognition and mood (e.g., aggression). Alterations in social systems and social learning and behavior are also generated by individuals experiencing altered sleep processes.
The NICHD supports and conducts research on sleep, circadian rhythm, disruptions in these areas, and effects of those disruptions. Some of this research is described below.
Institute Activities and Advances
The Child Development and Behavior Branch (CDBB) is interested in research and research training relevant to the influence of the quantity and quality of sleep on the psychological, psychobiological, language, behavioral, and educational development of young people from childhood through young adulthood. The CDBB is also interested in the relationship between sleep and social, affective, and cognitive development; aggression and violence; and health, and it has a corresponding interest in health promotion and health-risk behaviors. The CDBB is partnering with the National Heart, Lung, and Blood Institute to support Education Research (R25) Grant Applications to stimulate the development of education programs and tools in sleep health and circadian and sleep biology.
The Population Dynamics Branch (PDB) supports research and training on sleep and circadian rhythms within its mission in demography, reproductive health, and population health. Research includes studies relating sleep and circadian rhythms to demographic events and processes within the context of the long-reaching effects of early-life influences and policy factors (e.g., shift work, school schedules) on health. A study on the effects of language-based bedtime routines found that singing, reading, and storytelling at bedtime improved nighttime sleep duration and verbal test scores. In population health, the PDB supports research on human health—including productivity, behavior, and development—using defined populations and probability samples.
The Pediatric Growth & Nutrition Branch (PGNB) also has an interest in the relationship between sleep and childhood obesity, specifically the relationship between duration and/or quality of sleep and children’s eating and physical activity behaviors, as well as energy balance and weight control.
The Intellectual and Developmental Disabilities Branch (IDDB) supports grants that address sleep disturbances or altered circadian rhythms as part of conditions associated with developmental disabilities. These disabilities may include chromosomal disorders, such as Down Syndrome and other trisomies, and genetic syndromes, such as Fragile X syndrome, Rett Syndrome, and Cornelia de Lange syndrome. Some genetic conditions (e.g., Smith-Magenis syndrome) are associated with specific disruptions in sleep that can inform studies of normal and abnormal sleep. In addition, many individuals with Autism Spectrum Disorder, a seizure disorder, and/or self-injurious behaviors suffer from either sleep apnea or disrupted sleep cycles. Little is known about the nature of the sleep disorders or disruptions in circadian rhythm that occur in these conditions and the impact they have on the individuals and their family members.
The National Center for Medical Rehabilitation Research (NCMRR) is interested in improving our understanding of the impact of sleep quality during rehabilitation, including the development of research milestones that could lead to improved clinical practice and standards of care. There is a significant need for research that focuses on persons with physical and cognitive disorders and on individuals who develop chronic physical disabilities resulting from traumatic injury or other medical conditions, including stroke, multiple sclerosis, and cerebral palsy. Because sleep disturbances may occur in conjunction with other conditions that are secondary to the primary cause of disability, their potential effects could be difficult to define in relation to a specific medical condition and the overall functioning of the individual.
The Maternal & Pediatric Infectious Disease Branch (MPIDB) supports research on sleep and sleep disturbances in HIV-infected children, adolescents, and women. Researchers from the Pediatric HIV/AIDS Cohort Study found recently that HIV infection was associated with alterations in sleep duration and daytime sleep patterns, as well as neurocognitive factors.
The interests of the Pregnancy and Perinatology Branch (PPB) fall primarily within two areas: Sudden Infant Death Syndrome (SIDS) and sleep-disordered breathing (SDB) during pregnancy. In SIDS, efforts include research on its causes/etiology, identification of infants at risk, and development and implementation of risk reduction/preventive strategies. Supported research in SDB has indicated that there is an association between SDB and adverse pregnancy outcomes, such as preeclampsia, preterm birth, and fetal growth restriction. Furthermore, the intermittent hypoxia associated with SDB may lead to changes in the intrauterine environment that predispose offspring to metabolic and cardiovascular disorders. The PPB is also partnering with other organizations on the Lifestyle Interventions For Expectant Moms (LIFE-Moms) Consortium. Seven clinical trials on lifestyle interventions of overweight and obese pregnant women will collect data on sleep, including schedule, quantity, habits, disorders, and daytime sleepiness. The Consortium is funded by the NICHD and several other NIH Institutes.
The Fertility & Infertility (FI) Branch is currently studying sleep disorders in women with polycystic ovary syndrome and how these disorders might contribute to metabolic dysfunction.
Researchers in the Section on Neuroendocrinology, within the Division of Intramural Research, investigate the pineal gland and regulation of the hormone melatonin, which is produced by the pineal gland. This research aids the study of human diseases relating to circadian rhythms, including endocrine pathologies, sleep and mood disorders, and deficiencies in alertness. Researchers in the section also pursue a better understanding of the changes in gene expression that occur in the pineal gland over a 24-hour period.
Other Activities and Advances
- The Collaborative Home Infant Monitoring Evaluation (CHIME) Study, now complete, was a multicenter cooperative study of home monitoring that sought to determine whether home monitors are effective in identifying cardiorespiratory episodes that are dangerous to the infant's health.
- The National Infant Sleep Position (NISP) Study, conducted from 1992 to 2008, was a multicenter cooperative study of infant sleep aimed at assessing infant care practices and the dissemination of recommendations for infant sleep position.
- The Work, Family, Health, & Well-Being Initiative, supported by the NICHD PDB, seeks to improve the health and well-being of people in the workplace and families by identifying factors that improve worker performance and family health. The Initiative includes the Work, Family, & Health Network, which is co-funded by the PDB and the Centers for Disease Control and Prevention to conduct interdisciplinary research on the health and well-being of workers and their families.