Levin, Henry L
Formal Title:
Senior Investigator
Responsibilities:
Head of the research program that studies the impact and function of transposable elements.
Email:
henry_levin@nih.gov
Address:
18T Center Dr Room 106, MSC 5431
Bethesda Md 20892-5431
For FedEx use:
Bethesda Md 20892
Topics in my portfolio:
AIDS/HIV
Biosketch:
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INSTITUTION AND LOCATION
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DEGREE
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MM/YY
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FIELD OF STUDY
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Oberlin College, Oberlin
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B.A.
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5/81
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Chemistry
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University of California, Berkeley
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Ph.D.
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3/87
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Molecular Biology
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Johns Hopkins School of Medicine
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Postdoctoral
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11/92
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Molecular Biology
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Personal Statement
Henry Levin heads the Section on Eukaryotic Transposable Elements in the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, which analyzes LTR retrotransposons as a model for the replication of retroviruses. Levin’s studies of LTR retrotransposons in fission yeast identified mechanistic details of particle formation, reverse transcription, and integration. Recently, the laboratory demonstrated that Tf1 integration occurs primarily at promoters and used ultra-high throughput sequencing to generate a saturated map of sites targeted by Tf1. Dr. Levin has organized several conferences and symposia transposon biology and retrovirus replication. With in the last year he has been a principal co-organizer for the ASM sponsored International Conference on Mobile DNA and the Retrovirus Meeting held at the Cold Spring Harbor Laboratories. In 2009 he edited a special issue of the journal Methods on Transposon Technology and in 2011 he published a review of Transposon Biology in Nature Reviews Genetics. In 2011 Dr. Levin received the NIH Graduate Student Outstanding Mentor Award.
Publications (PubMed):
| Title |
Authors |
Publication |
Date |
| Epigenetic Regulation of Condensin-Mediated Genome Organization during the Cell Cycle and upon DNA Damage through Histone H3 Lysine 56 Acetylation. | Tanaka A,Tanizawa H,Sriswasdi S,Iwasaki O,Chatterjee AG,Speicher DW,Levin HL,Noguchi E,Noma KI | Mol Cell | 2012 Oct 17 |
| Dynamic interactions between transposable elements and their hosts. | Levin HL,Moran JV | Nat Rev Genet | 2011 Aug 18 |
| Comparative functional genomics of the fission yeasts. | Rhind N,Chen Z,Yassour M,Thompson DA,Haas BJ,Habib N,Wapinski I,Roy S,Lin MF,Heiman DI,Young SK,Furuya K,Guo Y,Pidoux A,Chen HM,Robbertse B,Goldberg JM,Aoki K,Bayne EH,Berlin AM,Desjardins CA,Dobbs E,Dukaj L,Fan L,FitzGerald MG,French C,Gujja S,Hansen K,Keifenheim D,Levin JZ,Mosher RA,Müller CA,Pfiffner J,Priest M,Russ C,Smialowska A,Swoboda P,Sykes SM,Vaughn M,Vengrova S,Yoder R,Zeng Q,Allshire R,Baulcombe D,Birren BW,Brown W,Ekwall K,Kellis M,Leatherwood J,Levin H,Margalit H,Martienssen R,Nieduszynski CA,Spatafora JW,Friedman N,Dalgaard JZ,Baumann P,Niki H,Regev A,Nusbaum C | Science | 2011 May 20 |
| Determinants that specify the integration pattern of retrotransposon Tf1 in the fbp1 promoter of Schizosaccharomyces pombe. | Majumdar A,Chatterjee AG,Ripmaster TL,Levin HL | J Virol | 2011 Jan |
| High-throughput sequencing of retrotransposon integration provides a saturated profile of target activity in Schizosaccharomyces pombe. | Guo Y,Levin HL | Genome Res | 2010 Feb |
| The Hermes transposon of Musca domestica and its use as a mutagen of Schizosaccharomyces pombe. | Park JM,Evertts AG,Levin HL | Methods | 2009 Nov |
| The chromodomain of Tf1 integrase promotes binding to cDNA and mediates target site selection. | Chatterjee AG,Leem YE,Kelly FD,Levin HL | J Virol | 2009 Mar |
| Retrotransposon Tf1 is targeted to Pol II promoters by transcription activators. | Leem YE,Ripmaster TL,Kelly FD,Ebina H,Heincelman ME,Zhang K,Grewal SI,Hoffman CS,Levin HL | Mol Cell | 2008 Apr 11 |
| The GP(Y/F) domain of TF1 integrase multimerizes when present in a fragment, and substitutions in this domain reduce enzymatic activity of the full-length protein. | Ebina H,Chatterjee AG,Judson RL,Levin HL | J Biol Chem | 2008 Jun 6 |
| Chromodomains direct integration of retrotransposons to heterochromatin. | Gao X,Hou Y,Ebina H,Levin HL,Voytas DF | Genome Res | 2008 Mar |
| Host genome surveillance for retrotransposons by transposon-derived proteins. | Cam HP,Noma K,Ebina H,Levin HL,Grewal SI | Nature | 2008 Jan 24 |
| The hermes transposon of Musca domestica is an efficient tool for the mutagenesis of Schizosaccharomyces pombe. | Evertts AG,Plymire C,Craig NL,Levin HL | Genetics | 2007 Dec |
| Stress management: how cells take control of their transposons. | Ebina H,Levin HL | Mol Cell | 2007 Jul 20 |
| The self primer of the long terminal repeat retrotransposon Tf1 is not removed during reverse transcription. | Atwood-Moore A,Yan K,Judson RL,Levin HL | J Virol | 2006 Aug |
| Specific recognition and cleavage of the plus-strand primer by reverse transcriptase. | Atwood-Moore A,Ejebe K,Levin HL | J Virol | 2005 Dec |
| The integrase of the long terminal repeat-retrotransposon tf1 has a chromodomain that modulates integrase activities. | Hizi A,Levin HL | J Biol Chem | 2005 Nov 25 |
| The long terminal repeat-containing retrotransposon Tf1 possesses amino acids in gag that regulate nuclear localization and particle formation. | Kim MK,Claiborn KC,Levin HL | J Virol | 2005 Aug |
| Retrotransposons and their recognition of pol II promoters: a comprehensive survey of the transposable elements from the complete genome sequence of Schizosaccharomyces pombe. | Bowen NJ,Jordan IK,Epstein JA,Wood V,Levin HL | Genome Res | 2003 Sep |
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