Yanovski, Jack A
Formal Title:
Senior Investigator
Address:
10 Center Dr Room 2-3142, MSC 1103
Bethesda Md 20892-1103
For FedEx use:
Bethesda Md 20892
Biosketch:
Jack A. Yanovski, MD, PhD is Chief of the Section on Growth and Obesity in the Program on Developmental Endocrinology and Genetics. Dr. Yanovski obtained his medical degree in 1986 at the University of Pennsylvania, where he was also awarded a PhD in Physiological Psychology in 1989. After residency training in Pediatrics at the Children’s Hospital of Philadelphia, Dr. Yanovski completed a fellowship in Pediatric Endocrinology at the National Institutes of Health, conducting clinical and basic research with Gordon Cutler in the Section on Developmental Endocrinology in the Developmental Endocrinology Branch, where he developed the dexamethasone-suppressed ovine corticotropin-releasing hormone test for the differential diagnosis of hypercortisolism. This test has become part of the standard armamentarium of tests used by endocrinologists. Dr. Yanovski then remained at the National Institutes of Health to serve as Chief of Pediatrics for the Warren Grant Magnuson Clinical Center from 1994-1998. In response to the growing problem of pediatric obesity, Dr. Yanovski returned to NICHD to create the Unit on Growth and Obesity in the NICHD’s Developmental Endocrinology Branch and serve as its Head.
Dr. Yanovski has carried out a series of clinical studies related to the evaluation and treatment of overweight and obesity in children and adults, as well as laboratory investigations of the molecular etiologies of obesity. His randomized controlled trials have elucidated the limitations of current pharmacotherapeutic approaches for treatment of pediatric obesity and his observational studies have demonstrated the importance of disinhibited eating behaviors for pediatric obesity. His lab has also elucidated the roles of the melanocortin 3 receptor and brain-derived neurotrophic factor in human body weight regulation. Dr. Yanovski has authored or co-authored over 200 manuscripts and he has served as a regular reviewer for the New England Journal of Medicine, Lancet, JAMA, and many other journals. He has served as a standing member of the NSCF, NIH Study Section, as a consultant for FDA advisory panels, and on the editorial boards of several obesity, pediatric, and endocrine journals. Dr. Yanovski has also served as Chair of The Obesity Society’s annual Scientific Meeting. Among other awards, he has received the Public Health Service’s Outstanding Service Medal for innovative studies on obesity.
Publications (PubMed):
| Title |
Authors |
Publication |
Date |
| Depressive symptoms and cardiorespiratory fitness in obese adolescents. | Shomaker LB,Tanofsky-Kraff M,Zocca JM,Field SE,Drinkard B,Yanovski JA | J Adolesc Health | 2012 Jan |
| Pediatric obesity: etiology and treatment. | Crocker MK,Yanovski JA | Pediatr Clin North Am | 2011 Oct |
| Longitudinal study of depressive symptoms and progression of insulin resistance in youth at risk for adult obesity. | Shomaker LB,Tanofsky-Kraff M,Stern EA,Miller R,Zocca JM,Field SE,Yanovski SZ,Hubbard VS,Yanovski JA | Diabetes Care | 2011 Nov |
| Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial. | Yanovski JA,Krakoff J,Salaita CG,McDuffie JR,Kozlosky M,Sebring NG,Reynolds JC,Brady SM,Calis KA | Diabetes | 2011 Feb |
| Effects of high and low glycemic load meals on energy intake, satiety and hunger in obese Hispanic-American youth. | Mirza NM,Klein CJ,Palmer MG,McCarter R,He J,Ebbeling CB,Ludwig DS,Yanovski JA | Int J Pediatr Obes | 2011 Jun |
| Core body temperature in obesity. | Heikens MJ,Gorbach AM,Eden HS,Savastano DM,Chen KY,Skarulis MC,Yanovski JA | Am J Clin Nutr | 2011 May |
| Disordered-eating attitudes in relation to bone mineral density and markers of bone turnover in overweight adolescents. | Schvey NA,Tanofsky-Kraff M,Yanoff LB,Checchi JM,Shomaker LB,Brady S,Savastano DM,Ranzenhofer LM,Yanovski SZ,Reynolds JC,Yanovski JA | J Adolesc Health | 2009 Jul |
| Energy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor. | Savastano DM,Tanofsky-Kraff M,Han JC,Ning C,Sorg RA,Roza CA,Wolkoff LE,Anandalingam K,Jefferson-George KS,Figueroa RE,Sanford EL,Brady S,Kozlosky M,Schoeller DA,Yanovski JA | Am J Clin Nutr | 2009 Oct |
| Salience of loss of control for pediatric binge episodes: does size really matter? | Shomaker LB,Tanofsky-Kraff M,Elliott C,Wolkoff LE,Columbo KM,Ranzenhofer LM,Roza CA,Yanovski SZ,Yanovski JA | Int J Eat Disord | 2010 Dec |
| The FTO gene rs9939609 obesity-risk allele and loss of control over eating. | Tanofsky-Kraff M,Han JC,Anandalingam K,Shomaker LB,Columbo KM,Wolkoff LE,Kozlosky M,Elliott C,Ranzenhofer LM,Roza CA,Yanovski SZ,Yanovski JA | Am J Clin Nutr | 2009 Dec |
| The stability of metabolic syndrome in children and adolescents. | Gustafson JK,Yanoff LB,Easter BD,Brady SM,Keil MF,Roberts MD,Sebring NG,Han JC,Yanovski SZ,Hubbard VS,Yanovski JA | J Clin Endocrinol Metab | 2009 Dec |
| Psychological symptoms and insulin sensitivity in adolescents. | Shomaker LB,Tanofsky-Kraff M,Young-Hyman D,Han JC,Yanoff LB,Brady SM,Yanovski SZ,Yanovski JA | Pediatr Diabetes | 2010 Sep |
| High adiposity and high body mass index-for-age in US children and adolescents overall and by race-ethnic group. | Flegal KM,Ogden CL,Yanovski JA,Freedman DS,Shepherd JA,Graubard BI,Borrud LG | Am J Clin Nutr | 2010 Apr |
| Long-term ritonavir exposure increases fatty acid and glycerol recycling in 3T3-L1 adipocytes as compensatory mechanisms for increased triacylglycerol hydrolysis. | Adler-Wailes DC,Guiney EL,Wolins NE,Yanovski JA | Endocrinology | 2010 May |
| Eating patterns in youth with and without loss of control eating. | Matheson BE,Tanofsky-Kraff M,Shafer-Berger S,Sedaka NM,Mooreville M,Reina SA,Vannucci A,Shomaker LB,Yanovski SZ,Yanovski JA | Int J Eat Disord | 2012 Dec |
| Puberty and observed energy intake: boy, can they eat! | Shomaker LB,Tanofsky-Kraff M,Savastano DM,Kozlosky M,Columbo KM,Wolkoff LE,Zocca JM,Brady SM,Yanovski SZ,Crocker MK,Ali A,Yanovski JA | Am J Clin Nutr | 2010 Jul |
| Challenges and opportunities of defining clinical leptin resistance. | Myers MG Jr,Heymsfield SB,Haft C,Kahn BB,Laughlin M,Leibel RL,Tschöp MH,Yanovski JA | Cell Metab | 2012 Feb 8 |
| Eating in the absence of hunger in adolescents: intake after a large-array meal compared with that after a standardized meal. | Shomaker LB,Tanofsky-Kraff M,Zocca JM,Courville A,Kozlosky M,Columbo KM,Wolkoff LE,Brady SM,Crocker MK,Ali AH,Yanovski SZ,Yanovski JA | Am J Clin Nutr | 2010 Oct |
| Acute effects of betahistine hydrochloride on food intake and appetite in obese women: a randomized, placebo-controlled trial. | Ali AH,Yanoff LB,Stern EA,Akomeah A,Courville A,Kozlosky M,Brady SM,Calis KA,Reynolds JC,Crocker MK,Barak N,Yanovski JA | Am J Clin Nutr | 2010 Dec |
| A prospective study of pediatric loss of control eating and psychological outcomes. | Tanofsky-Kraff M,Shomaker LB,Olsen C,Roza CA,Wolkoff LE,Columbo KM,Raciti G,Zocca JM,Wilfley DE,Yanovski SZ,Yanovski JA | J Abnorm Psychol | 2011 Feb |
| Links between mothers' and children's disinhibited eating and children's adiposity. | Zocca JM,Shomaker LB,Tanofsky-Kraff M,Columbo KM,Raciti GR,Brady SM,Crocker MK,Ali AH,Matheson BE,Yanovski SZ,Yanovski JA | Appetite | 2011 Apr |
| Self-reported vs. actual energy intake in youth with and without loss of control eating. | Wolkoff LE,Tanofsky-Kraff M,Shomaker LB,Kozlosky M,Columbo KM,Elliott CA,Ranzenhofer LM,Osborn RL,Yanovski SZ,Yanovski JA | Eat Behav | 2011 Jan |
| Obesity prevalence in the United States--up, down, or sideways? | Yanovski SZ,Yanovski JA | N Engl J Med | 2011 Mar 17 |
| Patients with Bardet-Biedl syndrome have hyperleptinemia suggestive of leptin resistance. | Feuillan PP,Ng D,Han JC,Sapp JC,Wetsch K,Spaulding E,Zheng YC,Caruso RC,Brooks BP,Johnston JJ,Yanovski JA,Biesecker LG | J Clin Endocrinol Metab | 2011 Mar |
| Adiposity and human regional body temperature. | Savastano DM,Gorbach AM,Eden HS,Brady SM,Reynolds JC,Yanovski JA | Am J Clin Nutr | 2009 Nov |
| An examination of the interpersonal model of loss of control eating in children and adolescents. | Elliott CA,Tanofsky-Kraff M,Shomaker LB,Columbo KM,Wolkoff LE,Ranzenhofer LM,Yanovski JA | Behav Res Ther | 2010 May |
| Subtyping children and adolescents with loss of control eating by negative affect and dietary restraint. | Goldschmidt AB,Tanofsky-Kraff M,Goossens L,Eddy KT,Ringham R,Yanovski SZ,Braet C,Marcus MD,Wilfley DE,Yanovski JA | Behav Res Ther | 2008 Jul |
| Loss of control eating disorder in children age 12 years and younger: proposed research criteria. | Tanofsky-Kraff M,Marcus MD,Yanovski SZ,Yanovski JA | Eat Behav | 2008 Aug |
| Effects of ritonavir on adipocyte gene expression: evidence for a stress-related response. | Adler-Wailes DC,Guiney EL,Koo J,Yanovski JA | Obesity (Silver Spring) | 2008 Oct |
| A prospective study of loss of control eating for body weight gain in children at high risk for adult obesity. | Tanofsky-Kraff M,Yanovski SZ,Schvey NA,Olsen CH,Gustafson J,Yanovski JA | Int J Eat Disord | 2009 Jan |
| Brain-derived neurotrophic factor and obesity in the WAGR syndrome. | Han JC,Liu QR,Jones M,Levinn RL,Menzie CM,Jefferson-George KS,Adler-Wailes DC,Sanford EL,Lacbawan FL,Uhl GR,Rennert OM,Yanovski JA | N Engl J Med | 2008 Aug 28 |
| Laboratory assessment of the food intake of children and adolescents with loss of control eating. | Tanofsky-Kraff M,McDuffie JR,Yanovski SZ,Kozlosky M,Schvey NA,Shomaker LB,Salaita C,Yanovski JA | Am J Clin Nutr | 2009 Mar |
| Effects of calcium supplementation on body weight and adiposity in overweight and obese adults: a randomized trial. | Yanovski JA,Parikh SJ,Yanoff LB,Denkinger BI,Calis KA,Reynolds JC,Sebring NG,McHugh T | Ann Intern Med | 2009 Jun 16 |
| Pediatric obesity: etiology and treatment. | Crocker MK,Yanovski JA | Endocrinol Metab Clin North Am | 2009 Sep |
| Validation of three food frequency questionnaires to assess dietary calcium intake in adults. | Sebring NG,Denkinger BI,Menzie CM,Yanoff LB,Parikh SJ,Yanovski JA | J Am Diet Assoc | 2007 May |
| Oxygen-uptake efficiency slope as a determinant of fitness in overweight adolescents. | Drinkard B,Roberts MD,Ranzenhofer LM,Han JC,Yanoff LB,Merke DP,Savastano DM,Brady S,Yanovski JA | Med Sci Sports Exerc | 2007 Oct |
| A multisite investigation of binge eating behaviors in children and adolescents. | Tanofsky-Kraff M,Goossens L,Eddy KT,Ringham R,Goldschmidt A,Yanovski SZ,Braet C,Marcus MD,Wilfley DE,Olsen C,Yanovski JA | J Consult Clin Psychol | 2007 Dec |
| Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. | Menzie CM,Yanoff LB,Denkinger BI,McHugh T,Sebring NG,Calis KA,Yanovski JA | J Am Diet Assoc | 2008 Jan |
| Phenotype and course of Hutchinson-Gilford progeria syndrome. | Merideth MA,Gordon LB,Clauss S,Sachdev V,Smith AC,Perry MB,Brewer CC,Zalewski C,Kim HJ,Solomon B,Brooks BP,Gerber LH,Turner ML,Domingo DL,Hart TC,Graf J,Reynolds JC,Gropman A,Yanovski JA,Gerhard-Herman M,Collins FS,Nabel EG,Cannon RO 3rd,Gahl WA,Introne WJ | N Engl J Med | 2008 Feb 7 |
| Insulin resistance, hyperinsulinemia, and energy intake in overweight children. | Han JC,Rutledge MS,Kozlosky M,Salaita CG,Gustafson JK,Keil MF,Fleisch AF,Roberts MD,Ning C,Yanovski JA | J Pediatr | 2008 May |
| Very low levels of energy expenditure among pre-adolescent Mexican-American girls. | Dugas LR,Ebersole K,Schoeller D,Yanovski JA,Barquera S,Rivera J,Durazo-Arzivu R,Luke A | Int J Pediatr Obes | 2008 |
| Laboratory-Based Studies of Eating among Children and Adolescents. | Tanofsky-Kraff M,Haynos AF,Kotler LA,Yanovski SZ,Yanovski JA | Curr Nutr Food Sci | 2007 |
| Psychometric properties of a new questionnaire to assess eating in the absence of hunger in children and adolescents. | Tanofsky-Kraff M,Ranzenhofer LM,Yanovski SZ,Schvey NA,Faith M,Gustafson J,Yanovski JA | Appetite | 2008 Jul |
| Structure analysis of the Children's Eating Attitudes Test in overweight and at-risk for overweight children and adolescents. | Ranzenhofer LM,Tanofsky-Kraff M,Menzie CM,Gustafson JK,Rutledge MS,Keil MF,Yanovski SZ,Yanovski JA | Eat Behav | 2008 Apr |
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