Skip Internal Navigation
Training and Education Opportunities
Postdoc: Molecular Biology/Biochemistry/Genetics/Developmental Biology
Two postdoc positions available July 1 to study mechanisms of epigenome reprogramming in mammals at the National Institutes of Health,
Bethesda, MD. The Section on Mammalian Epigenome Reprogramming headed
by Todd Macfarlan was established under the Earl Stadtman investigator
program, designed to facilitate high risk-high impact science (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way).
The laboratory uses a multi-disciplinary approach combining molecular,
biochemical, genetic, and cellular techniques to understand how
epigenomes are modified during mouse development, with particular
emphasis on the pre-implantation period and during development of the
central nervous system. Current projects include exploring the
context-dependent function of histone modifying enzymes during
development and during differentiation of stem cells, studying the
interplay of transcription factors and chromatin modifying enzymes
during artificial reprogramming, and exploring the impact of endogenous
retroviruses and their remnants on host genomes. Candidates will have
access to multi-dimensional imaging core facilities, substantial mouse
colony space, ample support for next generation sequencing applications
(ChIP-Seq, RNA-Seq, etc.), and outstanding stipend support.
Requirements:
Interested candidates must have a Ph.D. or M.D. within the past five
years in molecular biology, biochemistry, genetics, or a related field.
Experience with mouse genetics, mouse development, ES/iPS cell culture,
and/or next generation sequencing approaches is a plus.
To apply:
Send a coverletter with desired start date, a CV with bibliography, a
brief description of research experience and interests, and the names
of 3 references with contact information (including phone numbers) to todd.macfarlan@nih.gov.
Postdoc: Computational Scientist
A bioinformatics postdoctoral position is available July 1 to study
mechanisms of epigenome reprogramming in mammals at the National
Institutes of Health, Bethesda, MD. The Section on Mammalian Epigenome
Reprogramming headed by Todd Macfarlan was established under the Earl
Stadtman investigator program, designed to facilitate high risk-high
impact science (http://irp.nih.gov/careers/careers-in-action/science-the-stadtman-way).
The laboratory uses a multi-disciplinary approach combining molecular,
biochemical, genetic, and cellular techniques to understand how
epigenomes are modified during mouse development, with particular
emphasis on the pre-implantation period and during development of the
central nervous system. Current projects include exploring the
context-dependent function of histone modifying enzymes during
development and during differentiation of stem cells, studying the
interplay of transcription factors and chromatin modifying enzymes
during artificial reprogramming, and exploring the impact of endogenous
retroviruses on host genomes.
The candidate will work closely with experimental biologists to study
mechanisms of epigenome reprogramming, and will be expected to utilize
available tools and develop new tools for comparative genomics analysis
and analysis of next generation sequencing data (including ChIP-Seq,
mRNA-Seq, miRNA-Seq, etc.) Opportunities for extensive collaboration
with the NIH community are available.
Requirements:
The ideal candidate will have a Ph.D. in Computer Science,
Biostatistics or Bioinformatics within the past five years. Programming
skills with R, Python, Perl are required. Familiarity with Bowtie,
Tophat, Cufflinks, BWA, Samtools, Bedtools, Bamtools, Muscle, MACS, and
NCBI blast software is a plus, as is knowledge of on-line resources
including UCSC Genome Browser, NCBI, Ensemble, DAVID, genetontology.org
and AmiGO.
To apply:
Send a coverletter, a CV with bibliography, a brief description of
research experience and interests, and the names of 3 references with
contact information (including phone numbers) to todd.macfarlan@nih.gov.