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Overview
The Section on Molecular Morphogenesis, headed by Yun-Bo Shi, studies the gene-regulatory mechanisms controlled by thyroid hormone receptor (TR) that establish the metamorphosis program in Xenopus laevis. The group discovered that adult intestinal stem-cell formation requires both cell-autonomous function of TR and cell-cell interactions induced by TR and thus also revealed an evolutionally conserved role of the TR coactivator PRMT1 in adult stem-cell development in vertebrate intestine.