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The Section on Gamete Development, led by Mary Lilly, examines cell-cycle regulation during oogenesis. Over the past year, the Section continued to examine the pathways that coordinate meiotic progression with gamete differentiation. From these studies, the Section determined that the p27-like cyclin–dependent kinase inhibitor Dacapo promotes genomic stability during the premeiotic S phase of the oocyte. In addition, the Section identified a new pathway required to maintain mitotic quiescence during the highly conserved prophase I meiotic arrest of the oocyte. Lastly, the Section defined the role of a structural nucleoporin in promoting ovarian cyst divisions and the assembly of the meiosis I spindle.