Ruzong Fan, Ph.D

Current Position:

Investigator
Biostatistics and Bioinformatics Branch
Division of Epidemiology, Statistics, and Prevention
Eunice Kennedy Shriver National Institute of Child Health and Human Development
National Institutes of Health
Bethesda, MD 20892

Address:

6100 Executive Blvd, Room 7B07J
Bethesda, MD 20892-7510
fanr@mail.nih.gov

Education:

• 1998, Ph.D, Biostatistics, The University of Michigan, Ann Arbor, MI.

• 1996, M.S, Biostatistics, The University of Michigan, Ann Arbor, MI.

• 1988, Ph.D, Probability Theory, Chinese Academy of Sciences, Beijing, China.

• 1985, M.S, Probability Theory, Yunnan University, Kunming, China.

• 1983, B.S, Mathematics, Yunnan University, Kunming, China.

Research Interests:

• Statistical Genetics;

• Stochastic Modeling;

• Stochastic Processes and Applications.

NIH Experience:

• July 2011-present, Investigator, Biostatistics and Bioinformatics Branch, National Institute of Child Health and Human Development.

Previous Academic Appointments:

• 2006–2011, Associate Professor (tenured), Department of Statistics, Texas A&M University, Department of Epidemiology and Biostatistics, School of Rural Public Health, TAMU Health Science Center.

• 2008—2009, Visiting Associate Professor, Department of Epidemiology, MD Anderson Cancer Center, University of Texas, Houston, TX 77030.

• 2001–2006, Assistant Professor, Department of Statistics, Texas A&M University, Department of Epidemiology and Biostatistics, School of Rural Public Health, TAMU Health Science Center.

• 1999–2001, Assistant Professor, Department of Health Evaluation Sciences, College of Medicine, Pennsylvania State University.

• 1998–1999, Research Associate, Center for Biostatistics in AIDS Research, Harvard School of Public Health.

• 1994, Research Scientist, Institute of Applied Mathematics, University of Bonn, Germany.

• 1992–1993, Research Scientist, Department of Mathematics, Ruhr-University Bochum, Germany.

• 1991–1992, Research Scientist, Department of Mathematics, Humboldt-University Berlin, Germany.

• 1988–1991, Lecturer, Department of Probability and Statistics, Peking University, Beijing, China.

Academic and Professional Awards:

• 1982, Excellent Student Award, Yunnan University.

• 2001, Research Fellowship, The Alexander von Humboldt Foundation, Germany.

Steering Committee of Workshops:

• Next Generation Analytic Tools for Large Scale Genetic Epidemiology Studies of Complex Diseases, National Cancer Institute, NIH, 2010.

Chair of Statistical Meeting Sessions:

• August 2001, Section of Innovative Approaches for Teaching Statistical Topics, Joint Statistical meeting, Atlanta.

• 2004, Eastern North American Region/International Biometric Society.

Software Development:

• SAS Macros for Qualitative Traits (joint work with Dr. Knapp at University of Bonn, Germany):
  
  
  1. Hotelling T 2 Tests Based on Population Case Control Data.

  2. Hotelling T 2 Tests Based on Nuclear Trio Family Data.

  3. Hotelling T 2 Tests Based on Sib-ship Data.

• C++ Software to Detect Positive Selection in the Human Genome (joint work with Dr. Ming Zhong):
  
  
  1. Extended Homozygosity Score Test (EHHST).

  2. A Cross-population Extended Haplotype-based Homozygosity Score Test (xp-EHHST).

• Refer to DESPR BBB Software.

Teaching Experience:

• 2001-2011, Texas A&M University:
  
  
  1. Stat 211, Principles of Statistics I (undergraduate students).
     
     
  2. Stat 651, Statistics in Research I (Master students).
     
     
  3. Stat 652, Statistics in Research II (Master students).
     
     
  4. Stat 661, Statistical Genetics (Master students).
     
     
  5. Stat 662, Advanced Statistical Genetics (Ph.D students).
     
     
• 1999-2001, Pennsylvania State University:
  
  
  1. Statistical Genetics.
     
     
• 1988?1991, Peking University:
  
  
  1. Ergodic Theory.
     
     
  2. Martingale Limit Theory.
     
     
  3. Applied Stochastic Processes.
     
     
  4. Stochastic Differential Equations and Di?usion Processes.
     
     

Research Grants:

• 2007-2011, Genetic Basis for Exercise Training Responses, NIH/NHLBI 1R01 HL085918-01, Dr. Massett (PI), 5% effort, Biostatistician.

• 2005-2007, Haplotype Linkage and Association Mapping of Quantitative Trait Loci, DMS-0505025, The National Science Foundation, PI, $61,147.

• 2004, International Research Travel Assistance Grant, International Center, Texas A&M University, PI, $1,100.

• 2002, International Research Travel Assistance Grant, International Center, Texas A&M University, PI, $2,000.

• 2001-2002, Statistical Analysis in Complex Disease Gene Mapping, Pilot Project Program, Center for Environmental and Rural Health (CERH), Texas A&M University, PI, $20,000.

• 2001, Surfactant Proteins and Respiratory Distress Syndrome, NIH 4 R37 HL34788-15, Dr. Floros (PI), Collaborator as a Statistical Geneticist.

• 1999-2000, Pediatric Asthma Network Data Coordinating Center, NIH/NHLBI grant 1 U10 HL64313-01, Dr. Chinchilli (PI), Co-Investigator as a Statistical Geneticist.

• 1990–1992, Research Grant of Probability Theory and Stochastic Analysis, National Natural Science Foundation of China, PI.

Mentoring at Texas A&M:

• Visiting Scholar:

  1. 2010-2011, Dr. Shunfang Wang, School of Information Science and Engineering, Yunnan University, Kunming 650091, China.

• Ph.D students (advisor):

  1. 2001-2004, Jeesun Jung, Assistant Professor, Department of Medical and Molecular, Genetics, Indiana University, School of Medicine, Indianapolis, IN 46202, Thesis: High Resolution Linkage and Association of Quantitative Trait Loci.

  2. 2007-2011, Ming Zhong, Abbott, Research Statistician, Thesis: Extended Homozygosity Score Tests to Detect Positive Selection in Genome-wide Scans.

• Master Students (advisor):

  1. 2003-2004, Minghua Mei.

  2. 2003-2005, Lijun Ren.

  3. 2005-2007, Ming Zhong.

  4. 2007-2008, Lianfu Chen.

  5. 2008-2010, Yiwei Zhang.

  6. 2009-2010, Manxi Gu.

  7. 2008-2011, Qing Chang.

  8. 2009-2011, Jianxu Lu.

• Committee Member of Graduate Students in Statistics:

  1. 2002-2005, Dan Gaile (Ph.D).

  2. 2002-2004, Li-yu Liu (Ph.D).

  3. 2004-2006, Iryna Lobach (Ph.D).

  4. 2004-2006, Ilsung Chang (Ph.D).

  5. 2005-2007, Sanghan Lee (Ph.D).

  6. 2006-2008, Lian Liu (Ph.D).

  7. 2009-2011, Rupa Sridevi Kanchi (Ph.D).

  8. 2001-2002, Shaokun Chuai (M.S).

• Committee Member of Graduate Students Outside Statistics:

  1. 2005-2010, Xiaoyan Zhao (Ph.D).

  2. 2005-2009, Hao Xiong (Ph.D).

  3. 2005-2008, Haiwen Liu (Ph.D).

  4. 2006-2010, Tomasz E Koralews (Ph.D).

  5. 2006-2010, Yunhua Liu (Ph.D).

  6. 2009-2011, Igor Vilchez-Ramirez (Ph.D).

  7. 2002-2004, Wenbo Chen (M.S).

  8. 2005-2007, Reeta Krishna (M.S).

  9. 2005-2007, Shridhar Yamijala (M.S).

  10. 2006-2008, Ning Xu (M.S).

  11. 2006-2008, Le Jing (M.S).

  12. 2006-2008, Yen-hsuan Wu (M.S).

  13. 2007-2009, Xiaohong Zhu (M.S.).

  14. 2007-2009, Adam Ray Jarrett (M.S).

  15. 2008-2009, Hui Zhi (M.S).

Referee for Scientific Papers:

• February 2012, Bioinformatics.

• January 2012, research paper for“Analysis of Mixed Data”, CRC/Chapman & Hall.

• May 2011, Annals of Applied Statistics.

• May 2011, Statistics in Medicine.

• March 2011, Biomedcentral Bioinformatics.

• March 2011, Bioinformatics.

• February 2011, Statistical Applications in Genetics and Molecular Biology.

• 2010, Book review for CRC/Chapman & Hall, Annals of Human Genetics, Bioinformatics, Journal of Heredity, Genetic Epidemiology.

• 2009, Annals of Human Genetics, Genome Research, Applications and Applied Mathematics (AAM): an International Journal, BMC-series journals, Statistical Applications in Genetics and Molecular Biology.

• 2008, PLoS Genetics, Genetics, American Journal of Human Genetics, Biometrics, Advances in Bioinformatics, Genetic Epidemiology, Computational Statistics & Data Analysis.

• 2007,American Journal of Human Genetics, Statistical Applications in Genetics and Molecular Biology, Genetic Epidemiology.

• 2006, Biomedcentral Bioinformatics, Biometrics, Genetics, Current Progress in Bioinformatics, Biomedcentral Genetics.

• 2005, Genetics, Biomedcentral Genetics, Human Heredity, American Journal of Human Genetics, Federation of European Biomedical Societies Letters.

• 2004, American Journal of Human Genetics, Genetic Epidemiology, Biometrics, Proceedings of National Academy of Sciences USA.

• 2003, American Journal of Human Genetics, Nature Reviews Genetics, Human Heredity, Biometrics, Proceedings of National Academy of Sciences.

• 2002, Genetic Epidemiology, American Journal of Human Genetics, Bioinformatics.

• 2001, Human Heredity, American Journal of Human Genetics, Proceedings of the Short Course on Mathematical Biology, edited by Dr. Sneyd J, American Mathematical Society.

• 1999, Proceedings of National Academy of Sciences USA, Biometrics, Applied Mathematics Letters.

• 1998, Theoretical Population Biology.

Research Monograph:

• 1Albeverio S, Fan RZ, and Herzberg F (2011) Hyperfinite Dirichlet Forms and Stochastic Processes. The Lecture Notes of the Unione Matematica Italiana (UMI LN), Springer-Verlag, Volume 10.

Authorship is in alphabetical order of the last name. Dr. Fan contributed the first 4 chapters out of 6 as the main contributor.

Refereed Manuscripts:

1. Fan RZ, Zhang YW, Albert PS, Liu AY, Wang YJ, and Xiong MM (2012) Longitudinal association analysis of quantitative traits. Genetic Epidemiology, in press.

2. Lobach I, Fan RZ (2012) Genotype-based Bayesian analysis of gene-environment interactions with multiple genetic markers and misclassification in environmental factors. Journal of Probability and Statistics, in press.

3. Mechanic LE, Chen HS, Amos CI, Chatterjee N, Cox NJ, Divi RL, Fan RZ, Harris EL, et al. (2012) Next generation analytic tools for large scale genetic epidemiology studies of complex diseases. Genetic Epidemiology 36:22-35.

4. Fan RZ, Zhong M, Wang SF, Zhang YW, Andrew A, Karagas M, Chen H, Amos CI, Xiong M, and Moore J (2011) Entropy-based information gain approaches to detect and to characterize gene-gene and gene-environment interactions/correlations of complex diseases. Genetic Epidemiology 35:706-721.

5. Zhong M, Zhang YW, Lange K, and Fan RZ2 (2011) A cross-population extended haplotype-based homozygosity score test to detect positive selection in genome-wide scans. Statistics and Its Interface 4:51-63.

   2The corresponding author as a mentor of his Ph.D student, Dr. Zhong M.

6. Lobach I, Fan RZ3 , and Carroll RJ (2010) Genotype-based association mapping of complex diseases: a case-control approach of gene-environmental interactions with multiple markers and measurement errors in environmental exposures. Genetic Epidemiology 34:792-802.

   3The corresponding author. Fan RZ contributed the main idea and did most of the theoretical justification and was responsible to write the paper.

7. Zhong M, Lange K, Papp JC, and Fan RZ4 (2010) Extended homozygosity score tests to detect positive selection in genome-wide scans. European Journal of Human Genetics 18:1148-1159.

   4The corresponding author as a mentor of his Ph.D student, Dr. Zhong M.

8. Massett MP, Fan RZ, and Berk BC (2009) Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice. Physiological Genomics 40:15-22.

9. Chen LF, Zhong M, Chen WV, Amos C, and Fan RZ5 (2009) A genome-wide association scan for rheumatoid arthritis data by Hotelling’s T 2 tests. BMC Proceedings 3 (Suppl 7):S6.

   5The corresponding author as a mentor of his master student, Mr. Chen LF.
   

10. Thomas NJ, DiAngelo S, Hess JC, Fan RZ, Ball MW, Geskey JM, Will-son DF, and Floros J (2009) Transmission of surfactant protein variants and haplotypes in children hospitalized with respiratory syncytial virus. Pediatric Research 66:70-73.

11. Jung JS, Zhong M, Liu L, and Fan RZ6 (2008) Bi-variate combined linkage and association mapping of quantitative trait loci. Genetic Epidemiology 32:396-412.

    6The corresponding author as mentors of his students.
    

12. Fan RZ, Liu L, Jung J, and Zhong M (2008) Combined linkage and association mapping of quantitative trait loci with missing completely at random genotype data. Behavior Genetics 38:316-336.

13. Yang Q, Biernacka JM, Chen MH, Houwing-Duistermaat JJ, Bergemann TL, Basu S, Fan R, Liu L, Bourgey M, Clerget-Darpoux F, Lin WY, Dupuis J, Elston RC, and Cupples LA (2007) Group 4: using linkage and association to identify and model genetic effects. Genetic Epidemiology 31 (Supplement 1):s34-s42.

14. Thomas NJ, Fan RZ, DiAngelo S, Hess JC, and Floros Y (2007) Haplotypes of the surfactant protein genes A and D as susceptibility factors for the development of respiratory distress syndrome. Acta Paediatrica 96:985-989.

15. Pavlovic J, Papagaroufalis C, Xanthou M, Liu W, Fan RZ, Thomas NJ, Apostolidou I, Papathoma E, Megaloyianni E, DiAngelo S, and Floros J (2006) Genetic variants of surfactant proteins A, B, C, and D in Bronchopulmonary Dysplasia. Disease Markers 22:277-291.

16. Floros J, Thomas N, Liu W, Papagaroufalis C, Xanthou M, Pereira S, Fan RZ, Guo X, DiAngelo S, and Pavlovic J (2006) Family-based association tests suggest linkage between SP-B (and flanking region) and RDS; SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS. Pediatric Research 59:616-621.

17. Fan RZ, Jung JS, and Jin L (2006) High resolution association mapping of quantitative trait loci, a population based approach. Genetics 172:663686.

18. Fan RZ and Knapp M (2005) Sib-ship T 2 association tests of complex diseases for tightly linked markers. Human Genomics 2:90-112.

19. Jung JS, Fan RZ, and Jin L (2005) Combined linkage and association mapping of quantitative trait loci by multiple markers. Genetics 170:881898.

20. Fan RZ, Knapp M, Wjst M, Zhao CX, and Xiong MM (2005) High resolution T 2 association tests of complex diseases based on family data. Annals of Human Genetics 69:187-208.

21. Fan RZ, Spinka C, Jin L, and Jung JS (2005) Pedigree linkage disequilibrium mapping of quantitative trait loci. European Journal of Human Genetics 13:216-231.

22. Fan RZ and Jung SJ (2004) High resolution joint linkage disequilibrium and linkage mapping of quantitative trait loci based on sibship data. Human Heredity 56:166-187.

23. Fan RZ and Knapp M (2003) Genome association studies of complex diseases by case-control designs. American Journal of Human Genetics 72:850-868.

24. Fan RZ and Xiong MM (2003) Combined high resolution linkage and association mapping of quantitative trait loci. European Journal of Human Genetics 11:125-137.

25. Fan RZ and Xiong MM (2003) Linkage and association studies of QTL for nuclear families by mixed models. Biostatistics 4:75-95.

26. Fan RZ and Jung SJ (2003) Association studies of QTL for multi-allele markers by mixed models. Human Heredity 54:132-150.

27. Fan RZ and Xiong MM (2002) High resolution mapping of quantitative trait loci by linkage disequilibrium analysis. European Journal of Human Genetics 10:607-615.

28. Xiong MM, Fan RZ, and Jin L (2002) Linkage disequilibrium mapping of quantitative trait loci under truncation selection. Human Heredity 53:158-172.

29. Fan RZ, Floros J, and Xiong MM (2002) Models and tests of linkage and association studies of QTL for multi-allele marker loci. Human Heredity 53:130-145.

30. Fan RZ, Floros J, and Xiong MM (2001) Linkage transmission disequilibrium test of two unlinked disease loci; application to respiratory distress syndrome. Advances and Applications in Statistics 1:277-308.

31. Floros J, Fan RZ, Diangelo S, Guo XX, Wert J, and Luo JM (2001) SPB associations and interactions with SP-A in RDS in whites and blacks. Pediatric International 43:567-576.

32. Floros J, Fan RZ, Matthews A, DiAngelo S, Luo JM, Nielsen H, Dunn M, Gewolb I, Koppe J, vanSonderen L, Farri-Kostopoulos L, R¨amet M, Merrill J, and Robbins (2001) Family based transmission disequilibrium test (TDT) and case-control association studies reveal surfactant protein A (SP-A) susceptibility alleles for respiratory distress syndrome (RDS) and possible race differences. Clinical Genetics 60:178-187.

33. Floros Y and Fan RZ (2001) Surfactant protein (SP) B associations and interactions with SP-A in whites and black subjects with respiratory distress syndrome. Pediatric International 43:567-576. Biology of the Neonate 80 (Suppl 1):22-25.

34. Fan RZ and Lange K (2000) Asymptotic properties of the maximal subinterval of a Poisson process. Stochastic Processes, Physics and Geometry: New Interplays. II: A Volume in Honor of Sergio Albeverio; Conference Proceedings, Canadian Mathematical Society, Volume 29; edited by Gesztesy F, Holden H, Jost J, Paycha S, R¨ockner M, and Scarlatti S; pp 175-187.

35. Fan RZ and Lange K (1999) Diffusion process calculations for mutant genes in nonstationary populations. Statistics in Molecular Biology and Genetics, Institute of Mathematical Statistics, Lecture Notes-Monograph Series, Volume 33, Published by the Institute of Mathematical Statistics and the American Mathematical Society; Ed. Seillier-Moiseiwitsch F, pp 38-55.

36. Fan RZ, Lange K, and Pena E (1999) Applications of a formula for the variance function of a stochastic process. Statistics & Probability Letters 43-2:123-130.

37. Fan RZ and Lange K (1998) Models for haplotype evolution in a non-stationary population. Theoretical Population Biology 53:184–198.

38. Lange K and Fan RZ (1997) Branching process models for mutant genes in nonstationary populations. Theoretical Population Biology 51:118– 133; Erratum, Theoretical Population Biology 52:165.

39. Fan RZ (1996) Potential theory of hyperfinite Dirichlet forms. Potential Analysis, Netherlands 5:417–462.

40. Albeverio S, Fan RZ, R¨ockner M, and Stannat W (1995) A remark on coercive forms and associated semigroups. Partial Differential Equations and Mathematical Physics (Series: Operator Theory: Advances and Applications, Vol. 78, Birkh¨auser Verlag, Basel/Switzerland), Eds. Demuth M and Schulze B, pp 1–8.

41. Albeverio S and Fan RZ (1995) Representation of martingale additive functionals and absolute continuity of infinite dimensional symmetric diffusions. Dirichlet Forms and Stochastic Processes, Proceedings of the International Conference in Beijing, Eds. Ma ZM, R¨ockner M, and Yan J, pp 25–45.

42. Fan RZ (1995) Nonstandard construction of symmetric strong Markov processes associated with Dirichlet forms. Stochastic Processes, Physics and Geometry II, Proceeding of the International Conference in Locarno, Switzerland, Eds Albeverio S, Cattaneo U, and Merlini D, pp 247–277.

43. Fan RZ (1992) Some diffusion processes on the half-space and their associated Dirichlet forms (in Chinese). Acta Mathematica Sinica 35:418– 430.

44. Fan RZ (1992) Decomposition of a class of functionals and the predictable representation theorem on Banach spaces. Acta Mathematicae Applicatae Sinica, English Series 8:153–167.

45. Fan RZ (1992) Beurling-Deny formulae on Banach spaces. Acta Mathematica Scientia 12:79–84.

46. Fan RZ (1991) Decomposition of a class of functionals. Acta Mathematica Sinica, New Series 7:224–240.

47. Fan RZ (1991) Closabilities of certain symmetric forms on Banach spaces (in Chinese). Chinese Annals of Mathematics 12A:202–209.

48. Fan RZ (1990) Representation of martingale additive functionals on Banach spaces. Acta Mathematicae Applicatae Sinica, English Series 6:74–80.

49. Fan RZ (1989) An extension of Dynkin formula and probabilistic solutions of some second-order partial differential equations (in Chinese). Journal of Yunnan University, Natural Science Edition 11:10–14.

50. Fan RZ (1987) A class of stochastic differential equations with local time and the skew Brownian motion with two barriers (in Chinese). Chinese Journal of Applied Probability and Statistics 3:130–136.

Commentaries

1. Fan RZ, Albert PS, and Schisterman EF (2012) A discussion of longitudinal genetic analysis as well as gene-gene and gene-environment interactions of complex traits. Statistics in Medicine, in press.

Book Reviews:

1. Fan RZ (2012) Statistics in Human Genetics and Molecular Biology, by Cavan Reilly. The American Statistician 66:71-72.

Posters and Abstracts:

1. 2000 October, linkage disequilibrium mapping of quantitative trait loci under truncation selection. The American Society of Human Genetics 50th Annual Meeting, 1767, p319 (abstract).

2. 2000 October, family based transmission disequilibrium test reveals linkage between an SP-B-linked locus and RDS; SP-B linked alleles are susceptibility or protection factors for RDS. The American Society of Human Genetics 50th Annual Meeting, 1996, p366 (abstract).

3. 2001 October, combined linkage and association mapping of quantitative trait loci. The American Society of Human Genetics 51st Annual Meeting, 1252, p396 (abstract).

4. 2002 October, haplotype linkage disequilibrium mapping of quantitative trait loci. The American Society of Human Genetics 52nd Annual Meeting, 2360, p572 (abstract).

5. 2004 October, high resolution T 2 association tests of complex diseases using normal sibs as controls. The American Society of Human Genetics 54th Annual Meeting, 1989/F3, p365 (abstract).

6. 2008 November, multivariate combined linkage and association mapping of quantitative trait loci. The 18th International Genetic Epidemiology Society Annual Meeting.

7. 2009 October, a powerful extended homozygosity score test to detect positive selection in genome-wide scans. The American Society of Human Genetics 59th Annual Meeting.

8. 2011 October, entropy-based approaches to detect gene-gene and gene-environment interactions of complex diseases. The 12th International Congress of Human Genetics and The American Society of Human Genetics 61st Annual Meeting, 725W.

Invited Talks and Seminars

1. June 2011, extended homozygosity score tests to detect positive selection in genome-wide scans. School of Statistics and Mathematics, Yunnan University of Finance and Economics, Kunming, China.

2. June 2011, entropy-based information gain approaches to detect gene-gene and gene-environment interactions/correlations of complex diseases. Department of Statistics, Yunnan University, Kunming, China.

3. February 2011, entropy-based information gain approaches to detect gene-gene and gene-environment interactions/correlations of complex diseases. Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH.

4. October 2010, National Cancer Institute, NIH.

5. June 2010, Division of Intramural Research Programs, National Institute of Mental Health, NIH.

6. May 2010, Child Psychiatry Branch, National Institute of Mental Health, NIH.

7. October 2009, National Cancer Institute, NIH.

8. October 2008, Division of Biostatistics, University of Minnesota, MN.

9. September 2008, MD Anderson Cancer Center, The University of Texas, Houston.

10. December 2007, Mt Sinai Medical School, New York, NY.

11. December 2007, Columbia University, New York, NY.

12. February 2007, UCLA, CA.

13. August 2006, Bonn University, Germany

14. May 2006, University of Alabama at Birmingham, AL.

15. March 2006, Stanford University, CA.

16. September 2005, Case Western Reserve University, OH.

17. July 2004, University of Bonn, Germany.

18. June 2002, Hawaii International Conferences on Statistics, HI.

19. March 2000, Department of Statistics, Penn State University, College Park, PA.

20. May 1999, Department of Health Evaluation Sciences, Penn State University, Hershey, PA.

21. May 1999, Department of Biostatistics, University of Iowa, Iowa City, IA.

22. April 1999, Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA.

23. March 1999, Department of Biostatistics, University of North Carolina, Chapel Hill, NC.

24. March 1999, Department of Statistics, University of Georgia, Athens, GA.

25. March 1999, Anderson Cancer Center, University of Texas, Houston, TX.

26. June 1998, Department of Environmental Health, Harvard School of Public Health, Boston, MA.

27. April 1998, Department of Biostatistics, Washington University, St. Louis, MO.

28. April 1998, Department of Mathematics, University of South California, Los Angeles, CA.

29. March 1998, Department of Statistics, Iowa State University, Ames, IA.

30. March 1998, Comprehensive Cancer Center, University of Alabama, Birmingham, AL.

31. March 1998, Department of Statistics and Department of Biostatistics, University of Wisconsin, Madison, WI.

32. December 1997, School of Public Health, Columbia University, New York, NY.

33. September 1993, Department of Mathematics, University of Oslo, Norway.

34. August 1993, Oberwolfach Conference on Nonstandard Analysis, Germany.

35. July 1992, International Conference of Nonstandard Analysis, Blaubeuren, Germany.

36. November 1992, Department of Mathematics, University of Strasburg, France.

37. September 1991, Department of Mathematics, Humboldt University of Berlin, Germany.

38. June 1991, International Conference of Stochastic Processes, Physics and Geometry II, Locarno, Switzerland.

Contributed Talks

1. April 2012, International Biometric Society, East North American Region Meeting, Washington DC.

2. March 2005, International Biometric Society, East North American Region Meeting, Austin, TX

3. March 2004, International Biometric Society, East North American Region Meeting, Pittsburgh, PA.

4. March 2003, International Biometric Society, East North American Region Meeting, Tampa, Florida.

5. March 2002, International Biometric Society, East North American Region Meeting, Washington, DC.

6. August 2001, Joint Statistical Meeting, Atlanta, GA.

7. March 2001, International Biometric Society, East North American Region Meeting, Charlotte, North Carolina.

Other Working Experience:

• Summer 2010, Visiting Scholar, National Cancer Institute, NIH (Research and Travel Support from the Intergovernmental Personnel Act (IPA), National Cancer Institute, NIH, 25% effort and travel support).

• Summer 2006, Research Scientist, Institute of Applied Mathematics, University of Bonn, supported by The Alexander von Humboldt Foundation, Germany.

• Summer 2004, Research Scientist, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, supported by The Alexander von Humboldt Foundation, Germany.

• Summer 2002, Research Scientist, Institute of Medical Biometry, Informatics and Epidemiology, University of Bonn, supported by The Alexander von Humboldt Foundation, Germany.

• 1995–1998, Research Assistant, Department of Biostatistics, University of Michigan.

• 1994–1995, Teaching Assistant, Department of Biostatistics, University of Michigan.

• 1986–1988, Research Assistant, Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing, China.

• 1985–1986, Teaching Assistant, Department of Mathematics, Yunnan University, Kunming, China.

• 1984–1985, Research Assistant, Institute of Applied Mathematics, Chinese Academy of Sciences, Beijing, China.

• 1983–1984, Research Assistant, Department of Mathematics, Yunnan University, Kunming, China.

Grant Reviews:

• 2002, The Wellcome Trust, London, UK

Membership:

• 1998-2011, The American Society of Human Genetics.

• 1999-2011, The International Biometric Society.

• 2000-2011, The International Genetic Epidemiology Society.

• 2000-2011, The American Statistical Association.

• 2000-2011, The Institute of Mathematical Statistics.