March 9-14, 2014
Keystone Symposia Directors Fund; Scientific Contributions: Section on Eukaryotic Transposable Elements (SETE), Laboratory of Gene Regulation and Development (LGRD), Program in Cellular Regulation and Metabolism (PCRM), Division of Intramural Research (DIR), NICHD
Hilton Santa Fe Historic Plaza Hotel, Santa Fe, New Mexico
Transposable elements are powerful engines of evolution. They create the majority of genomic DNA in many eukaryotes, and they dramatically shape genetic content by causing mutations, rearrangements, and sequence duplications. The link between these transposon-mediated mutations and disease is of increasing significance. The sequencing of human populations demonstrates that active transposons are substantially more prevalent than previously thought. This conference aims to:
- Apply recent innovations in high-throughput sequencing and genome analysis to the study of transposon biology and genome evolution.
- Discuss the discovery of cellular systems that inhibit transposon activity as examples of the evolutionary arms race that exists between mobile DNA and their hosts.
- Describe active transposition during neurogenesis and in tumor cells and raise fundamental questions about the role of mobile DNA in brain development and cancer.
The objective of this symposium is to foster ties between leaders in the field of transposon biology with pioneers in genome analysis. Discussions of transposon activity and genome evolution will focus on mechanistic models. Methods applied to these problems will include molecular structures, biochemistry, expression studies, and bioinformatic analyses. The transposons and hosts represented in this meeting include diverse examples from eubacteria, archaea, protists, plants, and mammals.
For more information on the conference, visit http://www.keystonesymposia.org/14C2.
Dr. Henry L. Levin, SETE, LGRD, PCRM, DIR, NICHD
Tel: (301) 402-4281