Sponsored by
The National Institute of Child Health and Human Development
The National Institute of Diabetes and Digestive and Kidney Diseases
The Office of Rare Diseases
The Office of Research on Women's Health
National Institutes of Health
Department of Health and Human Services
Hyatt Regency Bethesda
One Bethesda Metro
Bethesda, Maryland 20814
November 10-11, 2005
Organizers
Jon Levine
Department of Neurobiology and Physiology
Northwestern University
Emilie Rissman
Department of Biochemistry and Molecular Genetics
University of Virginia
Louis DePaolo
Reproductive Sciences Branch
Center for Population Research
NICHD, NIH, DHHS
Agenda
Thursday, November 10th
| 8:00 am |
OPENING REMARKS
Louis DePaolo, Reproductive Sciences Branch, CPR, NICHD
Giovanna Spinella, Office of Rare Diseases, OD, NIH, DHHS |
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| 8:10 |
KEYNOTE ADDRESS
GnRH Research Through the Looking Glass
Margaret Wierman, University of Colorado Health Science Center |
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| Session I. |
DEVELOPMENT OF GNRH NEURONS
Chair: Ei Terasawa, University of Wisconsin |
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| 9:00 |
Linking Function, Origin, and Genetic Pathways in the Development of Gonadotropin-Releasing Hormone Cells
Kathleen Whitlock, Cornell University |
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| 9:30 |
Migration and Maturation of GnRH-1 Neurons
Susan Wray, NINDS, NIH, DHHS |
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| 10:00 |
Break |
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| 10:15 |
GnRH Neuron Migration: A Long and Winding Road
Stuart Tobet, Colorado State University |
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| 10:45 |
FGF Signaling Regulates GnRH Neuron Genesis, Migration and Axon Targeting
Pei-San Tsai, University of Colorado at Boulder |
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| Session II. |
PUBERTY
Chair: Tony Plant, University of Pittsburgh |
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| 11:15 |
The Discovery of New Genes Involved in the Neuroendocrine Control of Puberty
Sergio Ojeda, Oregon Health & Science University |
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| 11:45 |
Anatomical and Functional Characteristics of the GnRH Neuronal System: Relationship to Puberty
Cheryl Sisk, Michigan State University |
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| 12:15 pm |
Integration of Afferent Signals to GnRH Neurons by Two Distinct Populations of Kisspeptin Neurons in the Forebrain
Robert Steiner, University of Washington |
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| 12:45 |
Lunch |
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| Session III. |
CELLULAR BASIS OF PULSATILITY
Chair: Richard Weiner, University of California at San Francisco |
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| 2:00 |
Regulation of GnRH Secretion
Kevin Catt, NICHD, NIH, DHHS |
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| 2:30 |
The Clockworks in Reproduction: The Role of the Circadian Clock in GnRH Secretion
Pat Chappell, University of California, San Diego |
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| 3:15 |
Intrinsic Properties of GnRH Neurons that may Contribute to Pulse Generation
Suzanne Moenter, University of Virginia |
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| 3:45 |
Break |
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| Session IV. |
STEROID ACTIONS
Chair: Judith Turgeon, University of California at Davis |
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| 4:00 |
Unravelling Estrogen Feedback to GnRH Neurons with Transgenics
Alan Herbison, University of Otago, New Zealand |
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| 4:30 |
Expression of Ion Channels in GnRH Neurons; Role in Burst Firing
Oline Ronnekleiv, Oregon Health & Science University |
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| 5:00 |
Progesterone Receptors Mediating Negative Feedback: New and Fast, or Old or Slow?
Jon Levine, Northwestern University |
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| 5:30 |
Adjourn |
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Friday, November 11th
| Session V. |
Metabolic and Stress Regulation
Chair: Sally Radovick, Johns Hopkins Medical Institutes |
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| 8:00 am |
Interaction Between Energy Balance and the Regulation of GnRH Neurons: Lactation as a Model
M. Susan Smith, Oregon Health & Science University |
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| 8:30 |
Role and Actions of Cortisol in Mediating Stress-Induced Reproductive Suppression
Fred Karsch, University of Michigan |
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| 9:00 |
Regulation of GnRH by Stress and Energy Availability in Humans
Anne Loucks, Ohio University |
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| 9:30 |
Break |
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| Session VI. |
Environment and Behavior
Chair: Emilie Rissman, University of Virginia |
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| 9:45 |
GnRH Influence on Reproductive Behavior and Central Chemosensory Processing in Male Golden Hamster
Michael Meredith, Florida State University |
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| 10:15 |
The Role of Mammalian GnRH-II in the Coordination of Energy Balance and Reproduction
Alexander Kauffman, University of Virginia |
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| 10:45 |
From Genes to Behavior and from Birds to Humans: Conserved Properties of GnIH
George Bentley, University of California at Berkeley |
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| 11:15 |
Break |
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| Session VII. |
GNRH RECEPTORS AND SIGNALING
Chair: Ursula Kaiser, Brigham & Women's Hospital |
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| 11:30 |
Cell Signaling and the GnRH Receptor: Membrane Compartments, Signaling Complexes and Target Genes
Marc Roberson, Cornell University |
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| 12:00 pm |
Systems Biology and the Single Gonadotrope
Stuart Sealfon, Mount Sinai School of Medicine |
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| 12:30 |
Regulation of Trafficking of the GnRH Receptor
P. Michael Conn, Oregon Health & Science University |
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| 1:00 |
Lunch |
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| Session VIII. |
PHYLOGENY
Chair: Gloria Hoffman, University of Maryland |
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| 2:00 |
Ligand-Induced Selective-Signaling (LiSS) at the GnRH Receptor
Robert Millar, MRC Human Reproductive Science, Edinburgh |
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| 2:30 |
New Insights into the GnRH Neuronal System of Primates
Henrik Urbanski, Oregon Health & Science University |
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| Session IX. |
CLINICAL APPLICATIONS
Chair: Janet Hall, Massachusetts General Hospital |
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| 3:00 |
Multi-faceted role of GnRH-I and GnRH-II in Reproduction
Peter Leung, University of Vancouver, British Columbia |
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| 3:30 |
Upstream Determinants of GnRH Secretion : Evidence from Human Investigation
William Crowley, Massachusetts General Hospital |
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| 4:00 |
Testosterone, GnRH Frequency and the Evolution of PCOS
John Marshall, University of Virginia |
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| 4:30 |
Adjourn |
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